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Clin Cancer Res:简单血检预知癌症治疗效果

2017-10-02 佚名 medicalxpress

在一项新的研究中,加州大学圣地亚哥分校医学院的研究人员报告说,血液样本测试或液体活检可以预测哪些患者对抑制站点为基础的免疫疗法有反应。

在一项新的研究中,加州大学圣地亚哥分校医学院的研究人员报告说,血液样本测试或液体活检可以预测哪些患者对抑制站点为基础的免疫疗法有反应。

研究人员表示:“我们可以通过一种简单的血液测试中循环肿瘤DNA的突变数量,来帮助预测免疫治疗的反应。因为免疫治疗可能带来严重的副作用,因此准确找到适合的人群是至关重要的。”

研究结果发表在10月2日的《临床癌症研究》上,报告显示45%的患者在检测血液中循环肿瘤DNA时发现有超过三个基因改变。“检查站抑制剂免疫疗法的前景非常可观,对于目前所有类型的癌症患者都是如此。然而,截止到目前为止,超过80%的癌症患者无法应对检查点抑制剂免疫疗法”。

一旦激活使用检查点抑制剂免疫治疗,免疫系统需要识别癌细胞,癌细胞突变港口越多,它于正常组织的差别越突出,免疫系统也可以更好地识别目标肿瘤。在这个分析中,研究人员分析了来自69个不同类型的癌症患者的血液DNA,他们都在服用检查点抑制剂。“新方法可以帮助我们通过简单的血液样本确定哪些患者的免疫反应可能性有所增加,这项技术开辟了一个全新的免疫治疗方法。”

研究人员表示,接下来他们将进一步扩大临床试验的范围,进一步验证新型血检方法的精准度。

原始出处:

Yulian Khagi, Aaron M. Goodman, Gregory A. Daniels, et.al. Hypermutated Circulating Tumor DNA: Correlation with Response to Checkpoint Inhibitor–Based Immunotherapy. Clinical Cancer Research

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    2017-10-04 Luyuxie_11
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    2017-10-02 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2017-10-02 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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