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Pediatr Blood Cancer:在顺铂治疗后的儿童癌症幸存者中,不对称感官听力损失是晚发听力损失的风险因子

2018-10-30 AlexYang MedSci原创

耳毒性是顺铂化疗的一种明显的并发症。听力损失可以分成对称和不对称听力损失并且在治疗后可能减弱。最近,有研究人员调查了不对称听力损失(AHL)和晚发听力损失(LOHL)在顺铂治疗的儿科癌症患者中的风险。研究包括了993名患者的医疗和听力测定图标结果,时间在1990年的8月到2015年3月。研究发现,在进行AHL评估的患者中,26%的患者表现出了AHL。在LOHL评估的患者中,42%患者的听力在治疗完

耳毒性是顺铂化疗的一种明显的并发症。听力损失可以分成对称和不对称听力损失并且在治疗后可能减弱。最近,有研究人员调查了不对称听力损失(AHL)和晚发听力损失(LOHL)在顺铂治疗的儿科癌症患者中的风险。

研究包括了993名患者的医疗和听力测定图标结果,时间在1990年的8月到2015年3月。研究发现,在进行AHL评估的患者中,26%的患者表现出了AHL。在LOHL评估的患者中,42%患者的听力在治疗完成后恶化持续超过6个月。放射和癌症诊断类型是AHL和LOHL的主要的分线因子。进一步的是,LOHL与诊断的年龄、非颅辐射和更长时间的听力测定跟踪调查相关。另外,AHL与60%的同时携带AHL和LOHL的LOHL患者紧密相关。逻辑回归分析表明,患有AHL的患者(OR 6.3, 95% CI: 2.2-17.8, P = 0.0005)或者那些接受放射治疗的患者(OR 3.2, 95% CI: 1.2-8.6, P = 0.02)LOHL的风险更大。

最后,研究人员中指出,接受顺铂治疗的儿童处在AHL和LOHL的风险中。另外,对这些患者长期的检测是必要的,从而对听力减弱进行适时地的干预。

原始出处:


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    2019-04-09 feather89
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encryptionId=6eb91008e03b, topicName=风险因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2d411920658, createdName=cenghis, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=)]
  5. 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style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438795, encodeId=90061438e9564, content=<a href='/topic/show?id=5e61e13494d' target=_blank style='color:#2F92EE;'>#癌症幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71349, encryptionId=5e61e13494d, topicName=癌症幸存者)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, 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  6. 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style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438795, encodeId=90061438e9564, content=<a href='/topic/show?id=5e61e13494d' target=_blank style='color:#2F92EE;'>#癌症幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71349, encryptionId=5e61e13494d, topicName=癌症幸存者)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511127, encodeId=6a50151112e83, content=<a href='/topic/show?id=e1372836021' target=_blank style='color:#2F92EE;'>#儿童癌症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28360, encryptionId=e1372836021, topicName=儿童癌症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a3910291816, createdName=guozhenyu, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529271, encodeId=08f015292e100, content=<a href='/topic/show?id=6eb91008e03b' target=_blank style='color:#2F92EE;'>#风险因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100870, encryptionId=6eb91008e03b, topicName=风险因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2d411920658, createdName=cenghis, createdTime=Thu Nov 01 04:16:00 CST 2018, time=2018-11-01, status=1, ipAttribution=)]
    2018-11-01 ysjykql
  7. 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