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teriflunomide联合肿瘤靶向疗法可能会改善胶质母细胞瘤的治疗结果

2019-08-12 Allan MedSci原创

胶质母细胞瘤是一种侵入周围脑组织的侵袭性脑癌,因此手术治疗极为困难。即使化疗和放射成功地破坏了大部分患者的胶质母细胞瘤细胞,但化疗和放射可能不会影响癌症干细胞。这一小部分肿瘤细胞具有无限生长和繁殖的能力,并可导致肿瘤复发。

胶质母细胞瘤是一种侵入周围脑组织的侵袭性脑癌,因此手术治疗极为困难。即使化疗和放射成功地破坏了大部分患者的胶质母细胞瘤细胞,但化疗和放射可能不会影响癌症干细胞。这一小部分肿瘤细胞具有无限生长和繁殖的能力,并可导致肿瘤复发。

为了寻找胶质母细胞瘤的新疗法,加利福尼亚大学圣地亚哥分校医学院的研究人员使用携带人类胶质母细胞瘤细胞的小鼠,发现用靶向癌症疗法联合多发性硬化症(MS)药物teriflunomide可以阻止胶质母细胞瘤干细胞,显著缩小肿瘤并提高小鼠存活率。该研究于201987日在Science Translational Medicine上发表。


原始出处:

http://www.firstwordpharma.com/node/1658503?tsid=4#axzz5wLIhOPtA

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    2019-08-12 龙胆草

    学习谢谢分享

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肿瘤免疫治疗巨头百时美施贵宝(BMS)近日宣布,评估其PD-1肿瘤免疫疗法Opdivo(欧狄沃,通用名:nivolumab,纳武单抗)治疗多形性胶质母细胞瘤(GBM)的III期临床研究CheckMate-498(NCT02617589)未能达到延长总生存期(OS)的主要终点。

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赫尔辛基大学Pirjo Laakkonen教授领导的一个研究小组发现,胶质母细胞瘤细胞中小分子脂肪酸结合蛋白(MDGI或FABP3)的表达增加了它们侵入组织的能力,并且与较差的预后有关。

Radiology:复发胶质母细胞瘤动态对比增强MRI指标变异来源于哪里?

本研究旨在评价不同阅片者对胶质母细胞瘤患者行动态增强(DCE)MRI征象判读差异性(IRV)因素。

胶质母细胞瘤磁共振强化不明显一例

患者,女,42岁,因“轻度头晕,伴右侧视野偏盲”于2015年4月2日入山东大学附属临沂市人民医院。患者入院前8天出现轻度头晕,伴右侧视野偏盲,认知功能障碍,记忆力减退。无恶心、呕吐、肢体抽搐发作、大小便失禁。

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