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Arthritis Care Res:美国患有风湿性关节炎老兵病因死亡的调查结果

2015-06-27 范伟译 MedSci原创

背景:在风湿性关节炎的男性中对病因特异性死亡和相关的风险因素之间进行了有限的调查。我们调查患有风湿性关节炎男性所有死因以及病因特异性死亡,检查其存活的决定因素。方法:男性是从纵向风湿性关节炎RA注册中心招募进来直到死亡或整个2013年间的。使用全国死亡指数确定重要的状态和死因。计算所有死因,心血管疾病(CVD),癌症和呼吸道死亡的粗死亡率和标准化死亡率(SMRs)。采用多变量Cox比例风险和竞争-

背景:在风湿性关节炎的男性中对病因特异性死亡和相关的风险因素之间进行了有限的调查。我们调查患有风湿性关节炎男性所有死因以及病因特异性死亡,检查其存活的决定因素。

方法:男性是从纵向风湿性关节炎RA注册中心招募进来直到死亡或整个2013年间的。使用全国死亡指数确定重要的状态和死因。计算所有死因,心血管疾病(CVD),癌症和呼吸道死亡的粗死亡率和标准化死亡率(SMRs)。采用多变量Cox比例风险和竞争-风险回归方程,对所有死因及病因特异性死亡进行检查。

结果:风湿性关节炎RA的男性有1652人,332人死亡。心血管疾病CVD(31.6%;标准化死亡率1.77,95%置信区间1.46 -2.14),癌症(22.9%;标准化死亡率1.50;95%置信区间1.20 -1.89)和呼吸道疾病(15.1%;标准化死亡率2.90;95%置信区间2.20 -3.83)是死亡的主要原因。与死亡率相关的因素包括年龄、高加索种族、吸烟、较低的体重、并发症、疾病活动指数和强的松的使用。类风湿因子浓度与心血管疾病死亡率有关,而结节与心血管疾病和呼吸道相关死亡有关。甲氨蝶呤或生物药剂的使用与各种死因或病因特异性死亡无关联。

结论:在风湿性关节炎RA组里,男性所有死因以及病因特异性死亡有增加,在一般群体中呼吸相关的死亡风险相比同龄男性要高3倍。还需要进一步的研究来检验是否针对潜在的“可修改的”相关死亡率的干预措施可能导致风湿性关节炎的男性有改善的长期生存期。

原始出处:

England BR1, Sayles H1, Michaud K1,2, Caplan L3, Davis LA3,4, Cannon GW5, Sauer BC5, Solow EB6, Reimold AM6, Kerr GS7, Schwab P8, Baker JF9, Mikuls TR1.Cause-Specific Mortality in US Veteran Men with Rheumatoid Arthritis.Arthritis Care Res (Hoboken). 2015 Jun 19. doi: 10.1002/acr.22642. 

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    2015-06-29 lmm397
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    2015-06-29 zhaojie88
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