Dent Mater J：羟基磷灰石包裹改善TiO2纳米管表面的成骨细胞粘附和骨整合

2018-12-20 lishiting MedSci原创

这篇研究的目的是为了通过阳极氧化(AO)辅以额外的羟基磷灰石包裹构建钛(Ti)表面的TiO2纳米管图层以形成AO/HA表面。

这篇研究的目的是为了通过阳极氧化(AO)辅以额外的羟基磷灰石包裹构建钛(Ti)表面的TiO2纳米管图层以形成AO/HA表面。

体外细胞活性的检测显示，AO表面，特别是AO/HA表面，可以促进成骨细胞最初的粘附、增殖和分化。并且，改良AO和AO/HA表面可以上调成骨和粘附标志物的基因表达：I型胶原、骨桥蛋白(OPN)、骨钙素(OCN)和纽蛋白。另外，体内实验显示，AO表面、特别是AO/HA表面比Ti表现出更早的骨整合和更强的骨结合能力。

这些结果展示了纳米形貌和HA之间协同促进成骨细胞的粘附、增殖、分化和骨整合。结果代表了一种更有希望的改良种植体表面的方法。

原始出处：

Li Y， Li B， et al. Improved osteoblast adhesion and osseointegration on TiO2 nanotubes surface with hydroxyapatite coating. Dent Mater J. 2018 Dec 11. doi： 10.4012/dmj.2018-118.

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2018-12-22 zhaojie88

#成骨#

86 0
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2018-12-22 jj000004

#骨细胞#

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2018-12-22 bnurmamat

#骨整合#

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2018-12-22 爆笑小医

#羟基磷灰石#

103 0
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2018-12-20 惠映实验室

学习了，谢谢分享。

86 0
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2018-12-20 天地飞扬

了解一下，谢谢分享！

93 0

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