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Int J Cardiol:房颤患者心衰类型与血栓栓塞风险!

2018-04-23 xing,T MedSci原创

由此可见,该研究表明,LVEF减少与较高的血栓栓塞风险有关,但与较高的出血风险无关。HFHpEF是一个独特且令人困惑的类别,其特征是CHA2DS2-VASC评分最高,但血栓栓塞事件的残留风险最低,这值得进一步研究。

近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员旨在根据心力衰竭类型以评估心衰合并房颤患者的血栓栓塞和出血风险。

研究人员分析了6170例来自于欧洲房颤患者登记中心血栓栓塞事件预防研究的房颤患者,并将患者分为:左室射血分数降低的心衰患者(HFrEF;LVEF<40%);EF中等的心衰患者(HFmrEF;LVEF:40~49%);EF正常较低的心衰患者(HFpEF;LVEF:50~60%),EF正常较高的心衰患者(HFHpEF,LVEF>60%)和无心衰患者。该研究的结局为缺血性卒中、主要不良心血管和脑血管事件(MACE)和1年内发生的大出血。

研究人员发现卒中的年发病率与LVEF呈线性负相关,LVEF每下降1%,卒中发病率增加0.054%(95%CI为0.013%~0.096%;P=0.031)。HFHpEF患者的CHA2DS2-VASC评分最高,但卒中发生率显著低于其他心衰组(0.65%,HFLpEF为1.30%;HFmrEF 1.71%;HFrFF为1.75%;趋势P=0.014)。与其他心衰组相比,HFHpEF组(2%)MACCE的发生率也较低(范围为3.8~4.4%;P=0.001)。年龄、HF类型和NYHA级别是血栓栓塞事件的独立预测因素。相反,大出血事件组间差异无统计学意义(P=0.168)。

由此可见,该研究表明,LVEF减少与较高的血栓栓塞风险有关,但与较高的出血风险无关。HFHpEF是一个独特且令人困惑的类别,其特征是CHA2DS2-VASC评分最高,但血栓栓塞事件的残留风险最低,这值得进一步研究。

原始出处:


Jolanta M. Siller-Matula,et al. Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy.International Journal of Cardiology.2018. https://doi.org/10.1016/j.ijcard.2018.04.093

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    2018-04-24 张新亮1853311252142e2fm

    好文献.学习了

    0

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    2018-04-23 天地飞扬

    了解一下.谢谢分享!

    0

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