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Am J Resp Crit Care:儿童尿环境碳负荷:反映居住环境空气污染暴露的新标志物!

2017-07-08 xing.T MedSci原创

由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。

环境空气污染,包括黑碳污染,由于其致癌能力和气候污染物而导致了严重的公共卫生风险。迄今为止,尚未发现从循环到尿液清除的黑碳颗粒的内部暴露标记物。呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员开发并验证了一种无标记的测量尿液中黑碳颗粒的新方法。研究人员使用飞秒脉冲激光照射下产生的白色光来检测了289名儿童(9-12岁)尿液中碳负载。基于高分辨率时空插值方法估计儿童居住地的黑碳浓度。研究人员能够检测到所有儿童的尿黑碳,总体平均值(SD)为98.2×105(29.8×105)颗粒/毫升。尿黑碳负荷与慢性中期(一个月以上)住宅地的黑碳暴露呈正相关,即超过5.33×105颗粒/毫升的碳负载(95%可信区间为1.56×105到9.10×105颗粒/毫升)。一致的是,住在靠近主要道路的孩子(≤160米)有较高的尿黑碳负载(6.93×105颗粒/毫升;95%可信区间为0.77×105到13.1×105)。由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒

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  4. 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createdBy=a12645, createdName=智慧医人, createdTime=Sun Feb 11 08:32:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472558, encodeId=de3d14e2558ba, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Mon Jul 10 03:32:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220277, encodeId=e7512202e7a2, content=谢谢分享受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ae02063908, 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 08 20:07:47 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220038, encodeId=2bdc220038ca, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Jul 08 19:45:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220009, encodeId=8cbd220009c6, content=由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。, beContent=null, 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    2017-07-09 152****8376

    谢谢分享受益匪浅

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 中医痴

    不错的,学习了,谢谢分享!

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 半夏微凉

    学习了谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jul 09 07:33:15 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220053, encodeId=edec220053ee, content=最大受害者来反应,这个很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Jul 08 20:10:11 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220047, encodeId=feb722004e41, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 08 20:07:47 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220038, encodeId=2bdc220038ca, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Jul 08 19:45:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220009, encodeId=8cbd220009c6, content=由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 smartxiuxiu

    最大受害者来反应,这个很好!

    0

  8. 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createdName=152****8376, createdTime=Sun Jul 09 10:27:02 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220262, encodeId=735922026223, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jul 09 09:38:36 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220202, encodeId=c59b22020266, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jul 09 07:33:15 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220053, encodeId=edec220053ee, content=最大受害者来反应,这个很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Jul 08 20:10:11 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220047, encodeId=feb722004e41, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 08 20:07:47 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220038, encodeId=2bdc220038ca, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Jul 08 19:45:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220009, encodeId=8cbd220009c6, content=由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 131****1460

    学习了受益匪浅。

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 08 20:07:47 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220038, encodeId=2bdc220038ca, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Jul 08 19:45:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220009, encodeId=8cbd220009c6, content=由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 哈哈869

    66

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jul 09 07:33:15 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220053, encodeId=edec220053ee, content=最大受害者来反应,这个很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Jul 08 20:10:11 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220047, encodeId=feb722004e41, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jul 08 20:07:47 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220038, encodeId=2bdc220038ca, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Jul 08 19:45:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220009, encodeId=8cbd220009c6, content=由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 08 18:05:09 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 Julie W

    由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。

    0

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