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Nature:用于脑癌治疗的新型个体化治疗性疫苗进行首次人体试验

2018-12-25 MedSci MedSci原创

最近出版Nature杂志公布了I期GAPVAC-101研究的有利数据,测试了治疗具有特定的胶质母细胞瘤的新型治疗概念。

最近出版Nature杂志公布了IGAPVAC-101研究的有利数据,测试了治疗具有特定的胶质母细胞瘤的新型治疗概念。这种高度个性化的免疫疗法的可行性首次在多中心、多国临床环境中进行验证。胶质母细胞瘤(GBM)是脑癌中死亡率最高和最常见的一种,大多数的脑癌和胰腺癌都是由多形性胶质母细胞(神经胶质细胞)瘤形成的。52%的薄壁组织脑癌和20%的颅内脑癌是胶质母细胞瘤。不过虽然它是最常见的初发脑癌肿瘤,在北美和欧洲每十万人中仅发生两到三例。胶质母细胞瘤有巨细胞星形细胞瘤和神经胶质肉瘤两种。治疗方法包括化学疗法、放射疗法、放射手术、皮质甾类疗法、抗血管生成疗法和手术。迄今为止,患有胶质母细胞瘤的患者没有从免疫检查点抑制剂的最新突破中获益,因为在很大程度上,这种肿瘤类型的特征在于低突变负荷。


原始出处:

http://www.firstwordpharma.com/node/1613469#axzz5agmz8D1Z

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    2019-02-27 liye789132251
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1883500, encodeId=df8818835000d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Feb 27 20:28:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379765, encodeId=6db113e9765ee, content=<a href='/topic/show?id=193721289ea' target=_blank style='color:#2F92EE;'>#个体化治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21289, encryptionId=193721289ea, topicName=个体化治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Dec 27 11:28:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391897, encodeId=36df139189ed6, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Thu Dec 27 11:28:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435391, encodeId=d7d0143539197, content=<a href='/topic/show?id=9a5c212e88f' target=_blank style='color:#2F92EE;'>#个体化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21278, encryptionId=9a5c212e88f, topicName=个体化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Dec 27 11:28:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513638, encodeId=1c31151363830, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Dec 27 11:28:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356462, encodeId=de48356462b0, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Dec 26 12:02:53 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-26 kafei

    了解一下谢谢

    0

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