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ACS Appl Mater Interfaces:诱导相变可有效增强氧化石墨烯的干细胞分化能力

2018-04-05 MedSci MedSci原创

氧化石墨烯(GO)由于其独特的二维性质和功能化学特性,在多个领域引起了研究人员极大的兴趣。然而,对于其在干细胞培养和分化的应用而言,GO通常被还原形成还原型氧化石墨烯,导致氧含量的损失。在这里,我们在GO中诱导相变并证明其在增强干细胞培养和分化中的益处,同时保持氧含量。该转化导致GO表面上的氧原子聚集,极大地提高了其对细胞粘附的能力并增强人间充质干细胞(hMSC)向成骨谱系的分化。此外,修饰过的G

氧化石墨烯(GO)由于其独特的二维性质和功能化学特性,在多个领域引起了研究人员极大的兴趣。然而,对于其在干细胞培养和分化的应用而言,GO通常被还原形成还原型氧化石墨烯,导致氧含量的损失。

在这里,我们在GO中诱导相变并证明其在增强干细胞培养和分化中的益处,同时保持氧含量。该转化导致GO表面上的氧原子聚集,极大地提高了其对细胞粘附的能力并增强人间充质干细胞(hMSC)向成骨谱系的分化。此外,修饰过的GO结合能力增强,辅助成骨生长肽缀合检测验证了这点。

总的来说,我们的工作证明了GO在干细胞应用中的潜力,同时保持其氧含量,这可实现进一步功能化并制造新型纳米生物界面。

原始出处:


Yang JW, Hsieh KY, et al., Enhanced Osteogenic Differentiation of Stem Cells on Phase-Engineered Graphene Oxide. ACS Appl Mater Interfaces. 2018 Mar 30. doi: 10.1021/acsami.8b02225. 

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    2018-11-20 shanyongle
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    2018-04-07 yaanren
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1655855, encodeId=e0af16558550a, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Tue Nov 20 21:30:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956687, encodeId=e3e7195668eed, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Jun 04 08:30:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706970, encodeId=faaf1e06970af, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Sat Oct 27 15:30:00 CST 2018, time=2018-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651557, encodeId=168d165155e8d, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Wed Aug 22 02:30:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279252, encodeId=1de612e9252fa, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat Apr 07 07:30:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570203, encodeId=65a615e020348, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Sat Apr 07 07:30:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303038, encodeId=e777303038a0, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Apr 05 17:38:02 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303019, encodeId=f275303019a6, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Apr 05 16:37:05 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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    2018-04-05 虈亣靌

    优质资源.共同学习

    0

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