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ASCO 2022:经历过胃癌手术的患者,代谢综合征和脂肪肝患病风险较低

2022-06-01 MedSci原创 MedSci原创

在消化道恶性肿瘤中,胃癌发病率位居前列,然而,胃癌患者的代谢综合征和脂肪肝发病风险尚不清楚。

近年来,随着医疗水平的高速发展,癌症治疗的不断深入和优化,癌症幸存者的数量正在迅速增加。在消化道恶性肿瘤中,胃癌发病率位居前列,然而,胃癌患者的代谢综合征和脂肪肝发病风险尚不清楚。

近日,研究人员调查了与非癌症受试者相比,胃癌幸存者中代谢综合征和脂肪肝的患病率和患病风险,还分析了代谢功能障碍相关脂肪肝 (MAFLD) 的发病风险。研究结果已在2022年ASCO大会上公布。

在这项横断面研究中,研究人员招募了2014年~2019年Gangnam Severance医院进行健康体检的参与者。在经过年龄和性别 1:4 倾向评分匹配后,共纳入119名胃癌幸存者和476名非癌症受试者,其中,胃癌幸存者分为胃癌手术幸存者(OpGC)(n = 95)和非手术幸存者(non-OpGC)(n = 24)。MetS是通过代谢成分诊断的,脂肪肝是通过超声检查评估的。

结果显示,21.0%的胃癌幸存者和30.5%的非癌症受试者出现了MetS,13.7%的OpGC幸存者和50.0%的非OpGC幸存者出现了MetS。25.2%的胃癌幸存者和37.6%的非癌症受试者,以及21.1%的OpGC幸存者和41.7%的非OpGC幸存者观察到脂肪肝。

在调整年龄和性别后,OpGC 幸存者的 MetS 风险显著降低。与非癌症受试者相比,OpGC 幸存者的脂肪肝风险显著降低,但在非 OpGC 幸存者中则不然。与非癌症受试者相比,OpGC 幸存者代谢功能障碍相关脂肪肝疾病的风险明显降低。

总之,与非癌症受试者相比,OpGC 幸存者的MetS脂肪肝患病风险较低。未来,可进一步探索这些关联,以确保对胃癌幸存者进行及时的医疗干预。

原始出处

Hyojin Park.Risk of metabolic syndrome and fatty liver in gastric cancer survivors: A propensity score-matched analysis.

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