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Diabetologia:葡萄糖对痴呆风险的影响

2020-07-27 MedSci原创 MedSci原创

孟德尔随机化研究尚未显示高血糖与阿尔茨海默病风险的明确因果影响。本研究对遗传变异导致的高血糖对普通人群中未明确的痴呆,阿尔茨海默氏病和血管性痴呆的风险具有因果关系的假设进行了检验。

孟德尔随机化研究尚未显示高血糖与阿尔茨海默病风险的明确因果影响。本研究对遗传变异导致的高血糖对普通人群中未明确的痴呆,阿尔茨海默氏病和血管性痴呆的风险具有因果关系的假设进行了检验。

采用孟德尔随机设计对来自哥本哈根普通人口研究和哥本哈根城市心脏研究的115,875人的数据进行了研究。研究结果对阿尔茨海默氏病的研究结果在孟德尔双样本设计中得到验证,其中包括71,880名阿尔茨海默氏病患者或其父母患有阿尔茨海默氏病。

在观察性多因素校正分析中,未明确痴呆的HRs为1.15(95%CI 1.01,1.32; p = 0.039),阿尔茨海默氏病为0.91(95%CI 0.79,1.06; p = 0.22),而1.16(95%CI 0.86,血糖水平高于7 vs 5-6 mmol / l的个体中,血管性痴呆的患病率为1.55; p = 0.34)。患有和未患有2型糖尿病的个体相应的HRs为1.42(95%CI 1.24,1.63; p <0.001),1.11(95%CI 0.95,1.29; p = 0.18)和1.73(95%CI 1.31,2.27; p < 0.001)。在遗传因果分析中,血浆葡萄糖水平每升高1 mmol / l,未明确的痴呆的RRs为2.40(95%CI 1.18,4.89; p = 0.016),阿尔茨海默氏病的RRs为1.41(95%CI 0.82,2.43; p = 0.22)。血管性痴呆为1.20(95%CI 0.82,1.75; p = 0.36)。来自葡萄糖和胰岛素相关性状协会(MAGIC)的荟萃分析数据,以及阿尔茨海默氏病测序项目(ADSP),国际阿尔茨海默氏病项目(IGAP),阿尔茨海默氏病工作组精神病基因组学联盟(PGC-ALZ)和英国生物银行(UKB)给出了阿尔茨海默氏病的RR为1.02(95%CI 0.92,1.13; p = 0.42),并且该协会与哥本哈根研究相结合得出了阿尔茨海默氏病的RR = 1.03(95%CI 0.93,1.13; p = 0.36)。研究结果表明,观察到的和遗传性的高血糖与未指明的痴呆风险有因果关系,但与阿尔茨海默氏病或血管性痴呆没有关系。

原始出处:

Marianne Benn, Børge G. Nordestgaard,Impact of glucose on risk of dementia: Mendelian randomisation studies in 115,875 individuals

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    2020-07-28 junJUN

    老年人痴呆何药可用??

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