Baidu
map

JAHA:肾小球疾病患儿心血管疾病危险因素的患病情况

2019-07-09 xing.T MedSci原创

由此可见,原发性肾小球疾病的儿童表现出高频率的可改变的心血管危险因素,特别是未治疗的血脂异常。应定期测量血脂,以更好地确定该群体血脂异常的负担。目前筛查和治疗心血管危险因素的方法并不统一,突出了对基于证据的疾病特异性指南的需求。

血管疾病是慢性肾病患儿发病率和死亡率的主要原因。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员试图明确肾小球疾病患儿心血管危险因素的患病率,并描述目前关于危险因素识别和管理临床实践。

761名年龄在0至17岁的儿童,活检证实为原发性肾小球疾病(微小病变、局灶性节段性肾小球硬化、膜性肾病和IgA肾病/血管炎),这些患者均来自前瞻性治疗性肾小球肾病网络研究中,在肾小球疾病诊断时的中位数为16个月。在入组时确定传统(高血压、高胆固醇血症和肥胖)和新型(蛋白尿、早产和被动烟雾暴露)心血管危险因素的患病率,并比较肾小球疾病亚型。在肾小球疾病、类固醇暴露和缓解状态亚型中,比较了血脂异常的筛查频率和降脂或抗高血压药物的处方情况。

与一般人群相比,所有传统危险因素更为频繁;在这些筛查者中,21%患有高血压,51%患有超重或肥胖,71%患有血脂异常。招募时未达到缓解的儿童更容易患高血压和高胆固醇血症。14%的高血压儿童未接受抗高血压治疗。只有49%的患者接受了血脂异常的筛查,只有9%的血脂异常患者接受了降脂药物治疗。

由此可见,原发性肾小球疾病的儿童表现出高频率的可改变的心血管危险因素,特别是未治疗的血脂异常。应定期测量血脂,以更好地确定该群体血脂异常的负担。目前筛查和治疗心血管危险因素的方法并不统一,突出了对基于证据的疾病特异性指南的需求。 

原始出处:

Isa F. Ashoor.et al.Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.012143

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1765078, encodeId=82b31e650785a, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 25 22:53:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023767, encodeId=70432023e672f, content=<a href='/topic/show?id=9dfc518398d' target=_blank style='color:#2F92EE;'>#心血管疾病危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51839, encryptionId=9dfc518398d, topicName=心血管疾病危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sat Dec 07 16:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694146, encodeId=6bfe16941460d, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Sun Dec 29 02:53:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268177, encodeId=3c7a12681e78b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498597, encodeId=f562149859ef0, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1765078, encodeId=82b31e650785a, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 25 22:53:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023767, encodeId=70432023e672f, content=<a href='/topic/show?id=9dfc518398d' target=_blank style='color:#2F92EE;'>#心血管疾病危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51839, encryptionId=9dfc518398d, topicName=心血管疾病危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sat Dec 07 16:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694146, encodeId=6bfe16941460d, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Sun Dec 29 02:53:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268177, encodeId=3c7a12681e78b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498597, encodeId=f562149859ef0, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1765078, encodeId=82b31e650785a, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 25 22:53:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023767, encodeId=70432023e672f, content=<a href='/topic/show?id=9dfc518398d' target=_blank style='color:#2F92EE;'>#心血管疾病危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51839, encryptionId=9dfc518398d, topicName=心血管疾病危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sat Dec 07 16:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694146, encodeId=6bfe16941460d, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Sun Dec 29 02:53:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268177, encodeId=3c7a12681e78b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498597, encodeId=f562149859ef0, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1765078, encodeId=82b31e650785a, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 25 22:53:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023767, encodeId=70432023e672f, content=<a href='/topic/show?id=9dfc518398d' target=_blank style='color:#2F92EE;'>#心血管疾病危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51839, encryptionId=9dfc518398d, topicName=心血管疾病危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sat Dec 07 16:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694146, encodeId=6bfe16941460d, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Sun Dec 29 02:53:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268177, encodeId=3c7a12681e78b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498597, encodeId=f562149859ef0, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=)]
    2019-07-11 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1765078, encodeId=82b31e650785a, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 25 22:53:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023767, encodeId=70432023e672f, content=<a href='/topic/show?id=9dfc518398d' target=_blank style='color:#2F92EE;'>#心血管疾病危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51839, encryptionId=9dfc518398d, topicName=心血管疾病危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sat Dec 07 16:53:00 CST 2019, time=2019-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694146, encodeId=6bfe16941460d, content=<a href='/topic/show?id=595d8253132' target=_blank style='color:#2F92EE;'>#肾小球疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82531, encryptionId=595d8253132, topicName=肾小球疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=610229571547, createdName=meichuangyi, createdTime=Sun Dec 29 02:53:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268177, encodeId=3c7a12681e78b, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498597, encodeId=f562149859ef0, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Jul 11 08:53:00 CST 2019, time=2019-07-11, status=1, ipAttribution=)]
Baidu
map
Baidu
map
Baidu
map