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NEJM：胸膜间皮瘤早期生物标志物：fibulin-3

2012-12-14 佚名 手牵手博客

胸膜间皮瘤生物标志物石棉暴露
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　　科学家们尝试寻找新的生物标志物，用来早期检出胸膜间皮瘤，并制定相应的个体化治疗策略。为此纽约大学Langone医学中心的Harvey I. Pass教授及其研究团队通过研究后发现胸膜间皮瘤患者的fibulin-3显著升高，相关研究成果发表在《新英格兰医学杂志》（NEJM）上。 　　研究人员检测了92例间皮瘤患者、136名没有癌症的石棉暴露者（胸膜间皮瘤发病与接触石棉

　　科学家们尝试寻找新的生物标志物，用来早期检出胸膜间皮瘤，并制定相应的个体化治疗策略。为此纽约大学Langone医学中心的Harvey I. Pass教授及其研究团队通过研究后发现胸膜间皮瘤患者的fibulin-3显著升高，相关研究成果发表在《新英格兰医学杂志》（NEJM）上。

　　研究人员检测了92例间皮瘤患者、136名没有癌症的石棉暴露者（胸膜间皮瘤发病与接触石棉粉尘密切相关）、93例有渗出液的患者（非间皮瘤导致）和43名健康对照者的血浆fibulin-3水平。发现胸膜间皮瘤患者的fibulin-3水平显著高于非间皮瘤导致的渗出液的患者（P＜0.001）。早期间皮瘤患者与石棉暴露者的比较中，当fibulin-3 值为46.0 ng/ml时，其对于间皮瘤患者的敏感性为100%，特异性为94.1%。

　　上述研究表明：血浆fibulin-3水平可区分健康的石棉暴露者与间皮瘤患者，而联合渗出液与血浆fibulin-3水平可进一步区别渗出液是否来源于间皮瘤患者。

文章来源：

Pass HI, Levin SM, Harbut MR, Melamed J, Chiriboga L, Donington J, Huflejt M, Carbone M, Chia D, Goodglick L, Goodman GE, Thornquist MD, Liu G, de Perrot M, Tsao MS, Goparaju C.Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma.N Engl J Med. 2012 Oct 11;367(15):1417-27.


    

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    2013-11-08 lifestar

    #胸膜#

    0

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    2013-09-02 hukaixun

    #标志物#

    0

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    2012-12-16 zhu_jun9842

    #生物标志#

    0

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    2012-12-16 zhu_jun9842

    #生物标志#

    0

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    2012-12-16 1249884fm92暂无昵称

    #间皮瘤#

    0

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