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Stroke:中年时全身炎症与老年白质完整性与脑小血管病变有何关系?

2017-11-03 xing.T MedSci原创

由此可见,该研究结果支持这一假设,即中年时全身炎症反应可能会促进老年时慢性微血管结构性WM异常的发生发展。

中年时全身炎症是否会促进老年时白质(WM)异常和小血管病变的发生目前尚不清楚。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究旨在通过一个混血儿组成的前瞻性队列研究来评估中年时全身性炎症反应与老年时WM高信号体积、深部和脑室周围WM微观结构的完整性(各向异性分数和平均扩散[MD])、脑梗塞和微出血之间的关系。

研究人员采用线性和逻辑回归分析了中年时高敏C反应蛋白(CRP),一种非特异性炎症标志物,与21年后动脉粥样硬化风险之间的关系。

研究人员招募了1485名参与者(基础年龄为56 [5]岁;28%为黑人)。在调整了人口因素和心血管疾病后,中年时CRP每增加一个SD与较低的各向异性分数(-0.09;95%可信区间为-0.15至-0.02)和更大深部MD(0.08;95%可信区间为0.03至0.15)和较低的脑室周围WM各向异性分数(-0.07;95%可信区间为-0.13到0.0)。研究人员发现在黑人参与者中CRP和脑室周围WM显微结构完整性之间存在较强的联系(P=0.011)。在初步分析中,虽然较高的CRP水平和更大的WM高信号体积之间的相关性只在ApoEε4阳性参与者可以观察到(0.14;95%可信区间为0.01-0.26;相互作用P=0.028)。中年时CRP与老年时脑梗塞或脑微出血的存在无关。

由此可见,该研究结果支持这一假设,即中年时全身炎症反应可能会促进老年时慢性微血管结构性WM异常的发生发展。

原始出处:

Keenan A. Walker,et al. Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease The Atherosclerosis Risk in Communities Study.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.018675

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J Periodontal Res:牙龈炎可能参与了系统性疾病的发病机制

菌血症,系统性炎症标记物与牙周及系统性疾病之间存在着某些联系,且有可能参与了这些疾病的发病机制。本研究旨在探究牙龈炎的发展过程中系统性炎性标记物以及菌血症的变化。研究纳入80名研究对象,根据性别、是否吸烟以及牙龈出血位点数,将其随机分成两组:对照组(n=40)和实验性牙龈炎组(n=40)。对照组每天刷牙两次,使用常规氟化钠护齿牙膏和普通手动牙刷,配合使用牙线两次/每天,漱口水(含氟化物抗龋成分)漱

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