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eLife:吃夜宵?!上去的是体重,下来的是“智商”

2016-01-07 佚名 生物谷

图片来源:medicalxpress.com 偶然间的一次深夜小零食或许对身体是无害的,但近日一项刊登在eLife杂志上的最新研究指出,养成深夜吃零食的习惯或许会改变大脑的生理学结构。来自加利福尼亚大学的研究人员通过研究发现,正常情况下在应该睡眠的时间吃东西会导致大脑学习和记忆能力的缺失,而这些功能的发挥主要靠大脑的海马体结构来控制。 研究人员主要致力于研究在不合适的时间吃东西对大脑认知的

图片来源:medicalxpress.com

偶然间的一次深夜小零食或许对身体是无害的,但近日一项刊登在eLife杂志上的最新研究指出,养成深夜吃零食的习惯或许会改变大脑的生理学结构。来自加利福尼亚大学的研究人员通过研究发现,正常情况下在应该睡眠的时间吃东西会导致大脑学习和记忆能力的缺失,而这些功能的发挥主要靠大脑的海马体结构来控制。

研究人员主要致力于研究在不合适的时间吃东西对大脑认知的影响,因为我们都知道在不合适的时间吃东西会对机体代谢产生影响,比如会导致糖尿病前期的一些症状。研究者Dawn Loh说道,我们通过研究首次提出证据表明,在不合适的时间吃东西或会对个体的学习和记忆能力产生负面影响;很多人都会在本应该睡觉休息的时候工作或者玩乐,而这段时间恰恰是非常宝贵的,因为其对于维持大脑的功能是必不可少的。

研究者补充道,目前还没有在人类机体中对这一现象进行证实,但他们强调说,轮班的工人的认知能力往往表现较差。当前研究结果表明,相比其他行为而言,个体的学习行为确实会受到影响,文章中研究人员检测了小鼠识别新物体的能力,在睡眠时间进行规律进食的小鼠通常回忆某个物体的能力会大大下降,而且其大脑长期记忆的能力也会明显下降。

机体大脑中长期记忆和识别新物体的能力通常由大脑海马体结构来控制,而海马体在机体感知、记忆情绪体验及识别储存记忆方面扮演着重要的角色;在机体经历事情的过程中,神经冲动通常会沿着特殊的通路被激活,如果我们重复经历该事件,那么相同通路的效应强度就会增加,然而正常睡眠的6个小时如果被白天活动的6个小时替代的话,小鼠机体的这种效应就会明显降低。

某些参与生物钟和学习记忆能力的基因通常会被CREB蛋白所调节,而该蛋白是cAMP效应元件结合蛋白;当CREB活性较低时就会减少记忆力,而其在阿尔兹海默氏症的发病过程中也扮演着重要的角色。在错误时间喂食的小鼠,其大脑海马体中的CREB总量明显会降低,而其在白天的效应是最强的。然而生物钟系统的主要调节子—位于海马体中的视交叉上核却是不受影响的,这最终就会导致大脑不同区域间产生不同步性。

Christopher Colwell教授表示,当今人们的日常安排常常会导致我们在午夜吃东西,因此研究食物摄入时间对机体认知能力的影响非常重要。本文研究也首次提出了适当地调节进食时间或可改变海马体结构中的分子时钟并且改变小鼠机体的认知表现。在错误的时间里进食会干扰睡眠的模式,而这种不合适的进食规则也会导致睡眠总量中白天和夜晚差异的缺失,而这对于机体健康将会带来明显的影响。

原始出处:

Dawn H Loh, Shekib A Jami,et al, Misaligned feeding impairs memories.eLife.2015

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2068449, encodeId=d3332068449b3, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu Nov 10 00:20:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106665, encodeId=b7c210666544, content=研究不断深入,科学不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Mon Aug 29 08:07:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972951, encodeId=9c9719e295127, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 29 12:20:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55294, encodeId=b080552946f, content=古训有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55298, encodeId=5cba55298cc, content=过午不食, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54771, encodeId=a1d654e7108, content=以后不能吃夜宵了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90511609422, createdName=lindaliu, createdTime=Sat Jan 09 07:47:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322973, encodeId=a25013229e3f0, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Jan 09 01:20:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-11-10 clmlylxy
  2. [GetPortalCommentsPageByObjectIdResponse(id=2068449, encodeId=d3332068449b3, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu Nov 10 00:20:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106665, encodeId=b7c210666544, content=研究不断深入,科学不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Mon Aug 29 08:07:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972951, encodeId=9c9719e295127, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 29 12:20:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55294, encodeId=b080552946f, content=古训有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55298, encodeId=5cba55298cc, content=过午不食, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54771, encodeId=a1d654e7108, content=以后不能吃夜宵了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90511609422, createdName=lindaliu, createdTime=Sat Jan 09 07:47:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322973, encodeId=a25013229e3f0, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Jan 09 01:20:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-08-29 zibozhouping

    研究不断深入,科学不断进步

    0

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    2016-11-29 膀胱癌
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    2016-01-09 liuh2002

    古训有道理

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2068449, encodeId=d3332068449b3, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu Nov 10 00:20:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106665, encodeId=b7c210666544, content=研究不断深入,科学不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Mon Aug 29 08:07:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972951, encodeId=9c9719e295127, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 29 12:20:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55294, encodeId=b080552946f, content=古训有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55298, encodeId=5cba55298cc, content=过午不食, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54771, encodeId=a1d654e7108, content=以后不能吃夜宵了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90511609422, createdName=lindaliu, createdTime=Sat Jan 09 07:47:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322973, encodeId=a25013229e3f0, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Jan 09 01:20:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-01-09 liuh2002

    过午不食

    0

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    2016-01-09 lindaliu

    以后不能吃夜宵了?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2068449, encodeId=d3332068449b3, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu Nov 10 00:20:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106665, encodeId=b7c210666544, content=研究不断深入,科学不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Mon Aug 29 08:07:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972951, encodeId=9c9719e295127, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Tue Nov 29 12:20:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55294, encodeId=b080552946f, content=古训有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55298, encodeId=5cba55298cc, content=过午不食, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210629/6a7a0f3ccabb453db1ae369f6d6ce521/c360d68ef3d94b4e9e03ecdd0d529a09.jpg, createdBy=3c9b1571541, createdName=liuh2002, createdTime=Sat Jan 09 23:07:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=54771, encodeId=a1d654e7108, content=以后不能吃夜宵了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90511609422, createdName=lindaliu, createdTime=Sat Jan 09 07:47:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322973, encodeId=a25013229e3f0, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Jan 09 01:20:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-01-09 晓辰

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有人说:睡前吃东西会变肥?

“尤其是当你喜欢很早吃晚餐,或者经常在晚上活动(或者两者都做)的话,这样做会使你体内的血糖浓度在没有进食的漫漫长夜里得到稳定。”来自MD 安德森癌症中心的高级临床营养师斯蒂芬妮.马克松这样解释道。为什么你应该注重血糖浓度呢?正如大多数糖尿病患者所知道的,血糖和它所影响的激素会提高或者降低你的食欲和能量,除此之外还会干扰到体内储存或燃烧脂肪的功能。“低血糖会让人在早上觉得懒洋洋的,甚至会更难起床。”

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