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Hypertension:高血压患者血清磷酸盐与新发高尿酸血症风险

2019-05-13 xing.T 网络

总之,血清磷酸盐水平与高血压成人新发高尿酸血症的风险呈负相关。

血清磷酸盐与新发高尿酸血症的关系仍不确定。近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员的目的是评估血清磷酸盐与新发高尿酸血症风险的关系,并评估高血压患者任何可能的效应调节因子。

该研究是对CSPPT(中国卒中一级预防试验)研究中尿酸亚组研究的事后分析。目前的研究总共纳入了10612名基线正常尿酸水平(<357μmol/L [6mg/dL])的参与者。主要结局是新发高尿酸血症,其定义为男性尿酸浓度≥417μmol/L(7mg/dL)或女性≥357μmol/L(6 mg/dL)。

在4.5年的中位随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。总体而言,血清磷酸盐与新发高尿酸血症的风险之间存在显著的负相关(每增加一个SD的比值比为0.71; 95%CI为0.66-0.76)。当血清磷酸盐评估为四分位数时,与第一个四分位数(<1.2 mmol/L)的个体相比,处于第四个四分位数(≥1.4mmol/L;比值比为0.48; 95%CI为0.40-0.57)的参与者发生新发高尿酸血症的风险显著降低。在男性和女性中发现了类似的结果。

总之,血清磷酸盐水平与高血压成人新发高尿酸血症的风险呈负相关。 

原始出处:

Jingjing Cao.et al.Serum Phosphate and the Risk of New-Onset Hyperuricemia in Hypertensive Patients.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.12633

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    2020-04-17 feather89
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近年来,国内外几部重要的高血压指南陆续更新,一些新的循证证据和荟萃分析比较了各类降压药物的降压疗效及对心脑血管事件的影响。基于此,本共识专家组经反复讨论,达成一致意见并撰写《β受体阻滞剂在高血压应用中的专家共识》,旨在推动β受体阻滞剂在我国高血压患者中的合理应用。

这4种特殊类型高血压的治疗 不仅仅是降压这么简单

高血压是最常见的慢性病,是以动脉血压持续升高为特征的心血管综合征,其定义为在未使用降压药的情况下,非同日3次测量,收缩压≥140mmHg和/或舒张压≥90mmHg。近年来,随着研究的不断深入,发现部分患者的高血压类型比较特殊,是高血压中比较棘手的,只有针对它们的形成原因对症治疗,才能取得明显的效果。阻塞性睡眠呼吸暂停相关性高血压阻塞性睡眠呼吸暂停综合征(OSAS)导致血压升高的机制不明确。OSAS

Circulation:依帕列净可有效用于糖尿病合并高血压的黑人患者

Empagliflozin(依帕列净)是一种用于2型糖尿病(T2DM)的钠-葡萄糖共转运体2抑制剂,可降低T2DM患者的血压(BP)和心血管疾病的死亡率。但其是否可用于黑种人尚未有相关研究。研究人员开展一24周研究,评估依帕列净用于T2DM和高血压黑人患者的疗效和安全性。共招募了150位患者,52.7%为男性,平均年龄56.8(9.3)岁;平均T2DM患病时间9.3(7.1)年。起始时的重要参数:

大家来找茬:这5个高血压处方有哪些不合理的地方?

高血压是心内科最为常见的疾病之一,虽然高血压最新指南及大规模的临床试验提供了许多成熟的治疗方案,但很多临床医师在用药时仍存在一些误区,有些不合理处方中范的错误看似很“低级”,但是却可能给患者带来不可预知的后果。今天分享的5个不合理处方,都是高血压患者的用药案例,希望能给大家一些提醒和启发。

Journal Hypertension:氨肽酶A抑制剂QGC006治疗高血压的临床前结果

Quantum Genomics是一家生物制药公司,专注于开发直接针对顽固性高血压和心力衰竭的新药,Quantum Genomics近日宣布,在《Journal Hypertension》上发表了一项研究(DOI:10.1161 / HYPERTENSIONAHA.118.12499),介绍了脑穿透性氨肽酶A抑制剂QGC006治疗高血压的临床前结果。

J Hypertens:高血压和多种心血管危险因素会增加视网膜静脉阻塞的风险

由此可见,心血管危险因素比RVO存在的其他危险因素更重要。增加任何一个额外的危险因素,RVO的风险增加约40%,增加任何一个额外的心血管危险因素风险增加70%。

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