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Sci Transl Med:通过血液检测肿瘤基因,可预测肿瘤复发

2015-08-29 陈说 译 MedSci原创

现代医学面临的挑战之一就是如何得知癌症患者机体的肿瘤何时会复发。一项新的研究显示,可通过“跟踪突变”的血液检测可以发现肿瘤患者体内的复发迹象。ICR和皇家马斯登医院进行的这项研究为改变临床肿瘤监测方式和治疗决策具有十分重要的意义。判断肿瘤是否复发主要是依据血液中是否可以检测到肿瘤基因。它将会产生新的肿瘤细胞并导致机体肿瘤的复发。研究对象为55位乳腺癌早期术后的患者。通过对手术后的肿瘤患者进行血液监

现代医学面临的挑战之一就是如何得知癌症患者机体肿瘤的复发时机。一项新的研究显示,通过“跟踪突变”的血液检测可以发现肿瘤患者体内的复发迹象。ICR和皇家马斯登医院进行的这项研究为改变临床肿瘤监测方式和治疗决策具有十分重要的意义。


判断肿瘤是否复发主要是依据血液中是否可以检测到肿瘤基因。它将会产生新的肿瘤细胞并导致机体肿瘤的复发。

研究对象为55位乳腺癌早期术后的患者。通过对手术后的肿瘤患者进行血液监测,研究人员认为,通过每6个月进行一次的随访,已经能够准确预测哪位患者将会出现肿瘤的复发。

研究表明,血液肿瘤DNA检测阳性的患者肿瘤复发的几率是阴性患者的12倍。此外,血液肿瘤DNA检测到肿瘤复发的时间比出现肿瘤复发临床表现提早7.9个月。

英国癌症研究所的Kat Arney说道:“研究人员正在寻找可以检测到血液中肿瘤细胞释放的DNA的方法,并且可以用这种方法监测肿瘤是否复发,肿瘤DNA在血液中的含量如何改变,肿瘤在患者体内如何变化,并用此来监测肿瘤是否复发。由此便可不用对患者进行扫描或活检便得知肿瘤是否复发。”

Nicholas Turner认为,虽然这种方法的探究存在一定的困难和挑战,但是对乳腺癌患者大有裨益。因为研究者们在寻找乳腺癌基因存在的各种突变,他们发现这个血液检测可以应用于乳腺癌的所有分型。

Paul Workman教授说道:“这个血液检测可以帮助尽早得知肿瘤患者是否会出现肿瘤的复发,并且及早采取治疗措施,为患者争取更长的生存时间。”

原始出处:

Garcia-Murillas et al.Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.Science Translational Medicine.26 Aug 2015

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    2016-05-17 bsmagic9140
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    2015-09-04 fengzhigu

    0

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    2015-08-31 智智灵药

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