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J Dent:荟萃分析表明健康或牙周病人群中都存在牙龈卟啉单胞菌,程度轻重差异而已

2018-09-06 MedSci MedSci原创

牙周病是复杂的口腔疾病,其特征在于细菌诱导的牙齿支持组织的炎性破坏。牙龈卟啉单胞菌是一种常见的革兰氏阴性厌氧口腔细菌,与牙周病密切相关。本研究旨在通过Meta分析方法评估牙周病患者牙龈卟啉单胞菌的患病率。 研究人员搜索了包括PubMed,EmBase,Scopus,ISI Web of Science和Cochrane图书馆在内的不同数据库,以确定截至2014年12月牙周病中牙龈卟啉菌的检出

牙周病是复杂的口腔疾病,其特征在于细菌诱导的牙齿支持组织的炎性破坏。牙龈卟啉单胞菌是一种常见的革兰氏阴性厌氧口腔细菌,与牙周病密切相关。本研究旨在通过Meta分析方法评估牙周病患者牙龈卟啉单胞菌的患病率。

研究人员搜索了包括PubMed,EmBase,Scopus,ISI Web of Science和Cochrane图书馆在内的不同数据库,以确定截至2014年12月牙周病中牙龈卟啉菌的检出率。随机效应模型应用于荟萃分析,并使用Cochran检验和I2指数评估研究之间的异质性。漏斗图和Egger测试用于检查发表偏倚。使用STATA版本12进行统计分析。

研究共纳入42项符合条件的研究进行荟萃分析。总样本量为5884个人,包含2,576名健康人,平均年龄为37.21±7.45岁,和3308名牙周患者,平均年龄为44.16±8.35岁。总体而言,牙龈卟啉单胞菌的患病率在牙周疾病组中为78%[95%CI:74-81],在健康个体中为34%[95%CI:26-41]。与健康受试者相比,牙周病患者中牙龈卟啉单胞菌的患病率明显较高[分别为78%和34%]。

该研究表明,牙龈卟啉单胞菌高度存在于牙周病患者中,并且在牙周健康人群中也存在,尽管程度较轻。因此,牙龈卟啉单胞菌的存在增加了牙周病的患病几率,并且可以将其视为主要的潜在风险因素。

原始出处:

Rafiei M, Kiani F, et al., Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis. J Dent (Shiraz). 2018 Sep;19(3):232-242.

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    2019-07-26 venlin
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    2018-09-06 phoebeyan520

    学习了

    0

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