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Clin Infect Dis:后续革兰阴性菌血液培养有意义吗?

2017-12-26 梁舒瑶 环球医学

2017年发表在《Clin Infect Dis》的一项由美国科学家进行的研究,探讨了是否需要进行后续革兰阴性菌血液培养。

2017年发表在《Clin Infect Dis》的一项由美国科学家进行的研究,探讨了是否需要进行后续革兰阴性菌血液培养。

背景:血流感染仍然是发病和死亡的一个主要原因。革兰阴性杆菌(GNB)菌血症通常转瞬即逝,在起始进行适当抗菌治疗和病源控制后通常很快缓解。后续血培养(FUBC)的最佳治疗持续时间和效用尚未得到详尽研究。目前,通过临床判断确定革兰阴性菌菌血症。为了考察重复血培养的价值,研究者分析了500次菌血症发作,以确定FUBC的频率,并确定持续性菌血症的风险因素。

方法:在500次菌血症发作中,研究者回顾性分析了383次(77%)至少进行1次FUBC的发作。研究者检索了菌血症假定病源、FUBC时的抗菌状态、抗菌敏感性、出现发热、合并症(静脉中心线、导尿管、糖尿病、AIDS、终末期肾病和硬化)需要强化治疗,以及死亡。

结果:抗菌药使用不影响FUBC的阳性比例,除非细菌对经验性抗菌药物不敏感。FUBC当日发热与革兰氏阳性球菌(GPC)FUBC更高的阳性率相关,而非与GNB相关。重症监护室(ICU)的死亡和治疗与阳性FUBC不相关。GNB和GPC分别提取17个FUBC和5个FUBC,产生1个阳性结果。

结论:FUBC为GNB菌血症的管理带来较小的额外价值。血液培养的无限制使用对患者有严重影响,包括增加医疗成本、延长住院时间、不必要的咨询以及抗菌药不恰当的使用。

原始出处:
Canzoneri CN, Akhavan BJ, Tosur Z,et al.Follow-up Blood Cultures in Gram-Negative Bacteremia: Are They Needed?Clin Infect Dis. 2017 Nov 13;65(11):1776-1779. doi: 10.1093/cid/cix648.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1811462, encodeId=f32318114625b, content=<a href='/topic/show?id=1226880e67f' target=_blank style='color:#2F92EE;'>#菌血液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88076, encryptionId=1226880e67f, topicName=菌血液)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Tue May 01 23:57:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012534, encodeId=17ae20125346e, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Feb 23 10:57:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272762, encodeId=e0212e276216, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Dec 26 21:46:30 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272732, encodeId=127f2e2732eb, content=学习受益匪浅谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Dec 26 20:19:16 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1811462, encodeId=f32318114625b, content=<a href='/topic/show?id=1226880e67f' target=_blank style='color:#2F92EE;'>#菌血液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88076, encryptionId=1226880e67f, topicName=菌血液)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Tue May 01 23:57:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012534, encodeId=17ae20125346e, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Feb 23 10:57:00 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272762, encodeId=e0212e276216, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Dec 26 21:46:30 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272732, encodeId=127f2e2732eb, content=学习受益匪浅谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Dec 26 20:19:16 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-26 thlabcde

    好资料学习了!

    0

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    2017-12-26 清风拂面

    学习受益匪浅谢谢

    0

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