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JAMA Neurol:一氧化碳中毒急性脑损害的磁共振成像及迟发性神经后遗症

2018-02-05 zhangfan MedSci原创

研究认为,一氧化碳中毒后急性脑损伤与迟发性神经后遗症相关,中毒急性期扩散加权成像可有助于识别后遗症高危患者

迟发性神经后遗症是急性一氧化碳中毒的主要后遗症,目前尚无有效的预测方法。近日研究人员考察急性脑损伤后弥散加权成像与急性一氧化碳中毒后迟发性神经后遗症之间的关系。

研究在韩国开展,700名成年急性一氧化碳中毒患者参与,其中433人(61.9%)接受急诊扩散加权成像。研究对成像过程中出现的清晰、高信号、急性脑损害表现(b=1000 s/mm2)进行记录,研究的主要终点是迟发性神经后遗症,定义为出院后6周内新出现的任何神经症状或体征。

在完成随访研究的387名患者中,女性占37.0%,平均年龄42.0岁。104人弥散加权成像存在急性脑损伤,其中苍白球病变77例(19.9%),弥漫性病变13例(3.4%),局灶性病变57例(14.7%),9.6%的患者存在1种以上病变。幕上病变101例,幕下病变23例。101人(26.1%)出现迟发性神经后遗症。多变量逻辑回归分析显示,急性脑损伤与迟发性神经后遗症独立相关(aOR,13.93;95% CI,7.16-27.11)。急性脑损伤对迟发性神经后遗症预测的敏感性为75.2%,特异性为90.2%;阳性预测准确性为73.1%,阴性预测准确性为91.2%。

研究认为,一氧化碳中毒后急性脑损伤与迟发性神经后遗症相关,中毒急性期扩散加权成像可有助于识别后遗症高危患者。

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    2018-05-17 yinhl1978
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    2018-02-07 mashirong
  5. [GetPortalCommentsPageByObjectIdResponse(id=2034402, encodeId=0d7e2034402d6, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Thu May 24 23:15:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000300, encodeId=bb2d20003008e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu May 17 07:15:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941133, encodeId=d4c3194113366, content=<a href='/topic/show?id=70f919362ba' target=_blank style='color:#2F92EE;'>#一氧化碳中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19362, encryptionId=70f919362ba, topicName=一氧化碳中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Sat Oct 13 10:15:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319066, encodeId=defb131906617, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341605, encodeId=73e413416057d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418783, encodeId=2e791418e83f8, content=<a href='/topic/show?id=da8839121bb' target=_blank style='color:#2F92EE;'>#后遗症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285367, encodeId=c2c228536ef2, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Feb 05 13:24:39 CST 2018, time=2018-02-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2034402, encodeId=0d7e2034402d6, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Thu May 24 23:15:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000300, encodeId=bb2d20003008e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu May 17 07:15:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941133, encodeId=d4c3194113366, content=<a href='/topic/show?id=70f919362ba' target=_blank style='color:#2F92EE;'>#一氧化碳中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19362, encryptionId=70f919362ba, topicName=一氧化碳中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Sat Oct 13 10:15:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319066, encodeId=defb131906617, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341605, encodeId=73e413416057d, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418783, encodeId=2e791418e83f8, content=<a href='/topic/show?id=da8839121bb' target=_blank style='color:#2F92EE;'>#后遗症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Wed Feb 07 01:15:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285367, encodeId=c2c228536ef2, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Feb 05 13:24:39 CST 2018, time=2018-02-05, status=1, ipAttribution=)]
    2018-02-07 huirong
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    2018-02-05 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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