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Nanoscale:通过微/纳米结构磷酸钙生物陶瓷修复骨质疏松性骨缺损

2019-01-25 MedSci MedSci原创

在骨缺损的骨质疏松性骨折中实现足够的骨再生是一个特别关键的挑战。在本研究中,我们设计了一种由纳米粒子增强的微晶须骨架(nwCaP)组成的微/纳米结构磷酸钙生物陶瓷。与传统或中间生物陶瓷相比,这种夹层结构的生物陶瓷表现出更高的抗压强度,合适的降解速率和更好的细胞附着。在骨质疏松性骨缺损的大鼠模型中,nwCaP组显示出骨折发生率降低和有效的新骨替代率,如通过微CT分析所表征的。通过血清PINP水平和组

在骨缺损的骨质疏松性骨折中实现足够的骨再生是一个特别关键的挑战。在本研究中,我们设计了一种由纳米粒子增强的微晶须骨架(nwCaP)组成的微/纳米结构磷酸钙生物陶瓷。

与传统或中间生物陶瓷相比,这种夹层结构的生物陶瓷表现出更高的抗压强度,合适的降解速率和更好的细胞附着。在骨质疏松性骨缺损的大鼠模型中,nwCaP组显示出骨折发生率降低和有效的新骨替代率,如通过微CT分析所表征的。通过血清PINP水平和组织学染色揭示了在nwCaP组的缺陷区域内形成的骨形成率增加和新骨量增加。此外,基因微阵列研究表明促进骨生成可能归因于与nwCaP生物陶瓷共培养的细胞中选择性上调的成纤维细胞生长因子23(FGF23)表达。此外,使用源自骨质疏松大鼠的原代成骨细胞证实JAK2信号通路参与nwCaP诱导的FGF23表达的升高。

总的来说,该研究结果表明,微/纳米结构的生物陶瓷可以增强骨质疏松性骨再生,并为治疗骨质疏松症骨缺损提供了一种有前景的策略。

原始出处:

Zhao R, Chen S, et al., Healing of osteoporotic bone defects by micro-/nano-structured calcium phosphate bioceramics. Nanoscale. 2019 Jan 23. doi: 10.1039/c8nr09417a.

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    2019-02-18 redcrab
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    2019-01-27 lfcmxl
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    2019-01-27 Eleven17
  6. [GetPortalCommentsPageByObjectIdResponse(id=1793672, encodeId=64111e93672a4, content=<a href='/topic/show?id=e40315955e3' target=_blank style='color:#2F92EE;'>#scale#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15955, encryptionId=e40315955e3, topicName=scale)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Mon Aug 05 20:39:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776963, encodeId=f1f11e769637b, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Feb 18 03:39:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935334, encodeId=3e29193533402, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Tue Nov 05 12:39:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419285, encodeId=284e1419285de, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sun Jan 27 10:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592533, encodeId=69e315925333a, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Jan 27 10:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359224, encodeId=84ed3592247f, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Jan 25 21:24:12 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359222, encodeId=32a835922247, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Fri Jan 25 19:53:13 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-25 天地飞扬

    了解一下,谢谢分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1793672, encodeId=64111e93672a4, content=<a href='/topic/show?id=e40315955e3' target=_blank style='color:#2F92EE;'>#scale#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15955, encryptionId=e40315955e3, topicName=scale)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Mon Aug 05 20:39:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776963, encodeId=f1f11e769637b, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Feb 18 03:39:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935334, encodeId=3e29193533402, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Tue Nov 05 12:39:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419285, encodeId=284e1419285de, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sun Jan 27 10:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592533, encodeId=69e315925333a, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Jan 27 10:39:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359224, encodeId=84ed3592247f, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Jan 25 21:24:12 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359222, encodeId=32a835922247, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Fri Jan 25 19:53:13 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-25 医者仁心5538

    学习了

    0

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