Cell:PTPN12为三阴性乳腺癌抑癌基因

2011-03-25 MedSci原创 MedSci原创

　　《细胞》（Cell）杂志近期在线发表的一项研究结果显示，PTPN12是一种通常呈失活状态的抑癌基因。PTPN12酪氨酸磷酸酯酶通过对三阴性乳腺癌（TNBC）和其他肿瘤的多种原癌基因酪氨酸激酶靶向作用而抑制肿瘤进展。　　该研究通过基因筛查，确认PTPN12酪氨酸磷酸酯酶是一种TNBC抑癌因子。　　PTPN12可有效抑制乳腺上皮细胞增殖和转移，在人TNBC患者中常处于失活状态。该研究确定了

　　《细胞》（Cell）杂志近期在线发表的一项研究结果显示，PTPN12是一种通常呈失活状态的抑癌基因。PTPN12酪氨酸磷酸酯酶通过对三阴性乳腺癌（TNBC）和其他肿瘤的多种原癌基因酪氨酸激酶靶向作用而抑制肿瘤进展。

　　该研究通过基因筛查，确认PTPN12酪氨酸磷酸酯酶是一种TNBC抑癌因子。

　　PTPN12可有效抑制乳腺上皮细胞增殖和转移，在人TNBC患者中常处于失活状态。该研究确定了一种上游肿瘤抑制网络，对PTPN12有转录后控制作用。PTPN12磷酸酶通过抑制多种致癌酪氨酸激酶和与之相互作用而起到抑癌作用。通过恢复PTPN12功能或抑制PTPN12调节性酪氨酸激酶，PTPN12缺失TNBC细胞的癌变和转移潜能严重受损，从而提示TNBC依赖于受PTPN12限制的原癌基因酪氨酸激酶。

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2011-04-02 zhaozhouchifen

#Cell#

64 0
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2011-06-13 维他命

#CEL#

88 0
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2011-07-15 jingyanzhu715_39486108

#抑癌#

62 0
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2012-03-04 circumcision

#阴性乳腺癌#

87 0
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2011-03-27 12498484m46(暂无昵称)

#抑癌基因#

68 0
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2011-03-27 仁心济世

#癌基因#

94 0
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2011-03-27 xlysu

#三阴性#

83 0

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