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KIDNEY INT:糖尿病血液透析患者补充益生菌有好处!

2016-12-12 xing.T MedSci原创

在糖尿病血液透析患者中补充12周的益生菌能够对葡萄糖稳态参数、一些炎症和氧化应激的生物标志物发挥有益的效应。

近日,肾脏病领域权威杂志kidney international上发表了一篇来自伊朗卡尚医科大学附属医院内科的Alireza Soleimani医生及其团队的研究文章,旨在确定补充益生菌对糖尿病血液透析患者血糖控制、血脂浓度、炎症和氧化应激生物标志物的影响。

该研究在60名糖尿病血液透析患者中进行,为平行随机双盲安慰剂对照的临床试验。参与者在研究之初根据性别、透析和糖尿病时间、体重指数和年龄进行匹配。随后,他们被随机分为两组,分别服用含有酸乳杆菌、干酪乳杆菌和双歧杆菌等益生菌的胶囊或安慰剂12周。在整个研究过程中以三天为基础记录参与者饮食情况,饮食中宏观和微量营养素以及膳食纤维总量均无显著变化来混淆研究结果。

12周后,相比于接受安慰剂的患者,接受益生菌补充剂的患者空腹血糖(–22 vs.6.6mg/dl)、血清胰岛素(–6.4 vs. +2.3μIU/ml)、稳态模型评估的胰岛素抵抗(–2.9 vs. +2.5)、稳态模型评估的胰岛β细胞功能(–14.1 vs. +6.1)、糖化血红蛋白(–0.4 vs. –0.1%)和提高的定量胰岛素敏感性检测指数(0.03 vs. –0.02)均显著降低。此外,与安慰剂相比,接受益生菌补充剂导致血清高敏C反应蛋白(–1933 vs. +252ng/ml)、血浆丙二醛(–0.3 vs. +1.0μmol/L)、主观整体评估得分(–0.7 vs. +0.7)、总铁结合力(–230vs + 33μg/dl)显著减少,以及血浆总抗氧化能力显著增加(+15 vs. –88 mmol/l)。

因此,在糖尿病血液透析患者中补充12周的益生菌能够对葡萄糖稳态参数、一些炎症和氧化应激的生物标志物发挥有益的效应。

原始出处:

Alireza Soleimani,et al. Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. kidney international.2016.

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    2016-12-14 habb
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    2016-12-14 gwc389
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    2016-12-13 1e10c84am36(暂无匿称)

    现在糖尿病患者太多,越来越年轻化了

    0

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