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Diabetes Res Clin Pract:益生菌可显著降低2型糖尿病患者的空腹血糖

2016-07-12 MedSci MedSci原创

本研究旨在系统地评价益生菌对2型糖尿病(T2DM)干预的研究,并分析益生菌对T2DM患者血糖控制的影响。使用五个电子数据库进行电子搜索,检索日期设置为截止至2015年10月。对相关的研究进行鉴定、提取数据并评估偏倚的风险。主要研究结果是糖化血红蛋白(HbA1c)、空腹血糖(FBG)。次要研究结果为空腹胰岛素、稳态模型评估的胰岛素抵抗指数、C反应蛋白、白细胞介素-6和丙二醛。使用固定或随机效应模型汇

本研究旨在系统地评价益生菌对2型糖尿病(T2DM)干预的研究,并分析益生菌对T2DM患者血糖控制的影响。

使用五个电子数据库进行电子搜索,检索日期设置为截止至2015年10月。对相关的研究进行鉴定、提取数据并评估偏倚的风险。主要研究结果是糖化血红蛋白(HbA1c)、空腹血糖(FBG)。次要研究结果为空腹胰岛素、稳态模型评估的胰岛素抵抗指数、C反应蛋白、白细胞介素-6和丙二醛。使用固定或随机效应模型汇总益生菌组和对照组之间所有结果的平均差异(MD)。采用I2和Chi2试验评估统计学异质性。

研究共纳入六项随机对照试验(RCTs)进行系统评价,最终只有五项纳入荟萃分析。大部分RCTs研究的偏倚较小或不清楚。当与安慰剂组相比时,益生菌治疗组的FBG明显降低,异质性中等程度但并不明显。HbA1c和其他次要结果的组间差异较小。

总而言之,益生菌具有中等程度的降血糖作用,可明显降低FBG。但是,益生菌对于HbA1c、抗炎和抗氧化作用却并不一致。研究结果表明需要设计良好的临床研究进一步探讨益生菌在T2DM管理中的潜在益处。

原始出处:


Syamimi Samah, Kalavathy Ramasamy, et al., Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Res Clin Pract.2016;doi:10.1016/j.diabres.2016.06.014.


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