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JCLA:原发性干燥综合征患者唇腺淋巴细胞的免疫表型及临床特点

2019-01-17 MedSci MedSci原创

本研究的目的是探讨原发性干燥综合征(pSS)患者唇腺淋巴细胞免疫表型与外周血免疫表型的一致性。 研究人员选取71例pSS患者和35例颌面部外伤患者作为研究对象。根据71例pSS患者唇腺CD20与CD3比值,将其分为高表达组(48例)和低表达组(23例)。分析唇腺淋巴细胞免疫表型、病程、红细胞沉降率(ESR)、C反应蛋白、免疫球蛋白和补体水平。结果表明,pSS组唇腺IgG、IgA、IgM、C3

本研究的目的是探讨原发性干燥综合征(pSS)患者唇腺淋巴细胞免疫表型与外周血免疫表型的一致性。

研究人员选取71pSS患者和35例颌面部外伤患者作为研究对象。根据71pSS患者唇腺CD20CD3比值,将其分为高表达组(48)和低表达组(23)。分析唇腺淋巴细胞免疫表型、病程、红细胞沉降率(ESR)C反应蛋白、免疫球蛋白和补体水平。结果表明,pSS组唇腺IgGIgAIgMC3c水平均高于对照组,但C1q水平低于对照组(P< .05)。在所有pSS患者的唇腺标本中均可检测到CD20,其中CD3阳性66(93.0%),阴性5(7.0%)pSS患者血浆IgGIgAIgMCRPESR水平高于对照组,血清C4水平低于对照组(P< .01)CD20高表达组血清IgG水平、ESR、唇腺CD20均高于低表达组(P< .05)

原发性干燥综合征患者唇腺CD20阳性浸润淋巴细胞表达增高,在唇腺和外周血中均伴有免疫球蛋白和补体水平的改变。

原始出处:

Wenwen Sun, Na Zhang, Yujie Zhang, Zonghong Shao,Immunophenotypes and clinical features of lymphocytes in the labial gland of primary Sjogren's syndrome patients

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    2019-02-08 lixon1988

    学习一下

    0

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    2019-01-20 orangesking

    0

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    2019-01-19 tastas

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