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Metabolism:糖尿病对限制性和阻塞性肺功能损害影响!

2018-01-01 xing.T MedSci原创

由此可见,糖尿病与限制性肺功能损害有关,但与阻塞性肺功能损害无关。

近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员旨在评估糖尿病对限制性和阻塞性肺功能损害的影响。

这项为期5年的前瞻性研究纳入了7524名年龄在40-69 岁基线无肺功能损害患者,这些参与者在2008年4月和2009年3月之间接受全面的体检。糖尿病患者通过空腹血糖7≥mmol/L(126 mg/dL)、糖化血红蛋白≥ 6.5%(48mmol/mol)或糖尿病史来定义,随访由医生进行。限制性和阻塞性肺功能障碍分别被定义为用力肺活量(FVC)<预测的80%和第1秒用力呼气量(FEV1)与FVC比值(FEV1/FVC)<0.70。研究人员对参与者进行筛查,直到他们发展成限制性或阻塞性肺功能损害或直到2014年3月。

在随访期间,分别有171和639名参与者发生限制性和阻塞性肺功能损害。在调整性别、年龄、身高、腹型肥胖、吸烟、运动习惯、收缩压、高密度脂蛋白胆固醇、对数变换的超敏C反应蛋白和基线肺功能后,研究人员发现糖尿病患者发生限制性肺功能损害的风险比那些没有糖尿病参与者高1.6倍[多变量调整后的风险比和95%可信区间为1.57(1.04-2.36)]。相反,糖尿病患者没有明显增加阻塞性肺功能损害的风险[多变量调整的风险比和95%可信区间为0.93(0.72 - 1.21)]。

由此可见,糖尿病与限制性肺功能损害有关,但与阻塞性肺功能损害无关。

原始出处:


Nao Sonoda,et al. A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: the Saku study.Metabolism-Clinical and Experimental.2017. http://dx.doi.org/10.1016/j.metabol.2017.12.006

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    2018-01-19 guojianrong
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    2018-07-16 tomyang96
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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Jan 02 06:03:21 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274481, encodeId=c5fe2e4481b6, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Jan 01 13:20:06 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274463, encodeId=fa6a2e446396, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jan 01 11:09:04 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-02-09 一闲
  5. 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Jan 02 06:03:21 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274481, encodeId=c5fe2e4481b6, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Jan 01 13:20:06 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274463, encodeId=fa6a2e446396, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jan 01 11:09:04 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-03 曾超军

    谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1887801, encodeId=fb01188e80165, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Jan 19 05:16:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696792, encodeId=46f41696e92be, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Jan 02 06:03:21 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274481, encodeId=c5fe2e4481b6, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Jan 01 13:20:06 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274463, encodeId=fa6a2e446396, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jan 01 11:09:04 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-02 闆锋旦
  7. 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  9. 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Tue Jan 02 06:03:21 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274481, encodeId=c5fe2e4481b6, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon Jan 01 13:20:06 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274463, encodeId=fa6a2e446396, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jan 01 11:09:04 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-01 王秀

    学习了.涨知识了!

    0

  10. 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channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jan 01 11:09:04 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-01 明月清辉

    谢谢分享.学习了

    0

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