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Dent Mater J：掺杂多西环素的骨替代品对大鼠颅盖垂直性骨增长的影响

2018-12-08 lishiting MedSci原创

BODOX骨形成
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Bio-Oss (BO)是一种骨替代产品，因其较高的组织相容性和骨传导性广泛用做口腔领域内的骨充填物，然而它却不能刺激骨形成。多西环素(DOX)为广谱抗生素，对炎症和骨诱裂均表现出抑制作用，有研究报道它可刺激骨形成。这篇研究的目的是为了评估采用掺杂了DOX的BO对大鼠颅骨实施引导性骨再生后垂直性骨形成的影响。

Bio-Oss (BO)是一种骨替代产品，因其较高的组织相容性和骨传导性广泛用做口腔领域内的骨充填物，然而它却不能刺激骨形成。多西环素(DOX)为广谱抗生素，对炎症和骨诱裂均表现出抑制作用，有研究报道它可刺激骨形成。这篇研究的目的是为了评估采用掺杂了DOX的BO对大鼠颅骨实施引导性骨再生后垂直性骨形成的影响。研究对40只大鼠实施了垂直性颅盖骨增长的手术。其中，20只大鼠仅采用BO，另20只采用BO+DOX。在术后4和8周收集颅盖骨，通过放射性影像、组织学和RT-PCT进行评估。结果显示，4周时，BO+DOX矿化新骨形成的区域明显多于BO，并且TGFβ1， BMP2和β-catenin的表达在BO+DOX组中明显上调。这些结果表明，BO+DOX可以提高垂直性骨量的增加。原始出处：Zhang P， Ding L， et al. Effect of doxycycline doped bone substitute on vertical bone augmentation on rat calvaria. Dent Mater J. 2018 Dec 1. doi： 10.4012/dmj

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    2019-03-23 ms3415360956839622

    #骨增长#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1821546, encodeId=cc881821546d5, content=<a href='/topic/show?id=ea7510163412' target=_blank style='color:#2F92EE;'>#骨增长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101634, encryptionId=ea7510163412, topicName=骨增长)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Sat Mar 23 19:25:00 CST 2019, time=2019-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370596, encodeId=2baa13e0596c7, content=<a href='/topic/show?id=cca84345545' target=_blank style='color:#2F92EE;'>#多西环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43455, encryptionId=cca84345545, topicName=多西环素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Mon Dec 10 11:25:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354947, encodeId=498f35494e1f, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Dec 09 19:22:39 CST 2018, time=2018-12-09, status=1, ipAttribution=)]
    2018-12-10 珙桐

    #多西环素#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1821546, encodeId=cc881821546d5, content=<a href='/topic/show?id=ea7510163412' target=_blank style='color:#2F92EE;'>#骨增长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101634, encryptionId=ea7510163412, topicName=骨增长)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/JHX80Wpw3cstP6RtQ1pO8asyNiah0uIJwh7hmKm1emARpicBibTeQrj1SN7YwGSwibOrIL2kZ9WHmRiaznSnuHhUJUg/132, createdBy=c7de2500155, createdName=ms3415360956839622, createdTime=Sat Mar 23 19:25:00 CST 2019, time=2019-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370596, encodeId=2baa13e0596c7, content=<a href='/topic/show?id=cca84345545' target=_blank style='color:#2F92EE;'>#多西环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43455, encryptionId=cca84345545, topicName=多西环素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Mon Dec 10 11:25:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354947, encodeId=498f35494e1f, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Dec 09 19:22:39 CST 2018, time=2018-12-09, status=1, ipAttribution=)]
    2018-12-09 天地飞扬

    了解一下，谢谢分享！

    0

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