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JCEM:硒摄入量低或增加甲状腺疾病风险

2015-09-12 MedSci MedSci原创

西安交通大学医学院第一附属医院施秉银教授团队一项最新研究发现,在硒摄入量低的地区,甲状腺疾病风险也会增加,而提高这些地区人群硒摄入量可以降低甲状腺疾病患病风险。该研究发表在《临床内分泌代谢杂志》(JCEM)上。(J Clin Endocrinol Metab 2015 Aug 25)在这项横断面观察性研究中,研究人员对中国陕西省紫阳县和宁陕县两地共6152名居民的数据进行了评估,来调查这两个地区甲

西安交通大学医学院第一附属医院施秉银教授团队一项最新研究发现,在硒摄入量低的地区,甲状腺疾病风险也会增加,而富硒地区人群甲状腺疾病患病风险较低。该研究发表在《临床内分泌代谢杂志》(JCEM)上。


在这项横断面观察性研究中,研究人员对中国陕西省紫阳县和宁陕县两地共6152名居民的数据进行了评估,来调查这两个地区甲状腺疾病的患病率是否存在不同。这两个地区中,紫阳县是富硒地区(n = 3038),土壤中的硒含量充足,宁陕县是贫硒地区(n = 3114),土壤中硒含量缺乏。

所有参与者于2013年3月至5月进入研究,并根据土壤硒含量、乡镇位置和性别进行分层。所有参与者年龄都在18-70岁之间,且在相同的村庄居住超过5年,符合研究条件。

研究人员通过问卷调查对受试者进行调查,共有43个项目,涵盖人口资料、个人/家庭甲状腺疾病史、用药史和吸烟饮酒情况,以及简单的食物频率问卷(FFQ),调查茶叶、肉、蛋、盐(加碘或不加碘)和海带的摄入量。对参与者进行临床检查、甲状腺超声波检查和空腹抽血检查等。

通过测定血清促甲状腺激素、甲状腺素、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺激素受体抗体(TRab)浓度、甲状腺体积和甲状腺结节大小来判定被调查者是否患有甲状腺疾病。通过logistic回归分析分析硒水平、饮食因素和甲状腺疾病之间的关系。

富硒地区人群(103.6 ?g/L;)的血清硒浓度中位值是贫硒地区(57.4 ?g/L)人群血清硒浓度中位值的两倍(P< 0 .05)。富硒含地区较贫硒地区,甲状腺功能减退、亚临床甲状腺功能减退、自身免疫性甲状腺炎和甲状腺增大等甲状腺疾病发生率显著降低(18% 比 30.5%;P < 0.001)。提高血清硒浓度可以使下述疾病的发病率下降:自身免疫性甲状腺炎(OR = 0.47; 95% CI,0.35-0.65),亚临床甲减(OR = 0.68; 95% CI, 0.58-0.93),甲状腺功能减退(OR = 0.75; 95% CI, 0.63-0.9),甲状腺增大(OR = 0.75; 95% CI,0.59-0.97)。上述结果表明,硒与多种甲状腺疾病存在关联。

不过,研究人员表示,尽管试验结果表明硒摄入量低与甲状腺疾病之间存在相关性,但尚需进行更深入的研究来确定此种相关性是否存在因果关系。

另外,研究人员还认为:“这种大型人口流行病学调查尚属首次,这两地居民的遗传学、文化、生活方式和碘状态相似,但居住地的土壤硒浓度存在巨大差异,这种差异也使二县食物中的硒含量有差异。由此可见,富硒地区与贫硒地区甲状腺疾病患病率明显不同,表明硒缺乏与甲状腺疾病风险密切相关。”

原始出处:

Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B.Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab. 2015 Aug 25:jc20152222.

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    2015-10-28 smallant2015
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    2015-10-08 lmm397
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    2016-03-03 achengzhao
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    2015-09-14 娜样爱妮

    就这么改改顺序 来源就变了真的好么?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777523, encodeId=3c9c1e7752397, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Oct 28 07:52:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860578, encodeId=5a1c18605e88f, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Oct 08 02:52:00 CST 2015, time=2015-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062905, encodeId=55c92062905b1, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Mar 03 11:52:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472968, encodeId=a92b14e296816, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Mon Sep 14 13:52:00 CST 2015, time=2015-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36886, encodeId=340b3688671, content=就这么改改顺序 来源就变了真的好么?, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=822c1645128, createdName=娜样爱妮, createdTime=Mon Sep 14 09:17:00 CST 2015, time=2015-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36869, encodeId=01a13686927, content=这个研究非常不错,样本量很大,很有说服力, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Sep 13 08:32:00 CST 2015, time=2015-09-13, status=1, ipAttribution=)]
    2015-09-13 medcardio

    这个研究非常不错,样本量很大,很有说服力

    0

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