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Virology：科学家们改造出水泡性口炎嵌入病毒可以靶向消除脑肿瘤

2018-08-07 木木 病毒学界

VSV脑肿瘤水泡性口炎病毒
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水泡性口炎病毒（VSV）具有潜在的靶向杀死肿瘤细胞的能力，但因其具有亲神经的糖蛋白对正常脑细胞具有威胁。近日，来自美国的科学家们将基孔肯雅热病毒的多聚蛋白E3-E2-6K-E1基因嵌入至VSV基因组中，替换掉VSV糖蛋白基因，发现该改造后的病毒具有靶向消灭脑肿瘤细胞的能力。

水泡性口炎病毒（VSV）具有潜在的靶向杀死肿瘤细胞的能力，但因其具有亲神经的糖蛋白对正常脑细胞具有威胁。近日，来自美国的科学家们将基孔肯雅热病毒的多聚蛋白E3-E2-6K-E1基因嵌入至VSV基因组中，替换掉VSV糖蛋白基因，发现该改造后的病毒具有靶向消灭脑肿瘤细胞的能力。目前，该研究成果已发表至《Virology》杂志，题为“Chikungunya-vesicular stomatitis chimericvirus targets and eliminates brain tumors”。

研究人员使用改造后的VSV感染患有脑肿瘤小鼠，发现感染后的小鼠存活率上升。更为有趣的是，研究人员发现静脉注射的VSV只感染癌细胞，不感染正常的细胞。



该研究成果证实了改造后VSV能够靶向消灭脑肿瘤细胞，为抗肿瘤新药的开发提供了一条新的研发方向。

原始出处：Zhang X1, Mao G1, van den Pol AN2. Chikungunya-vesicular stomatitis chimeric virus targets and eliminates brain tumors. Virology. 2018 Jul 25;522:244-259.

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    2019-07-09 ms3892185887221420

    #Virol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2077381, encodeId=b02720e738190, content=<a href='/topic/show?id=cb141845040' target=_blank style='color:#2F92EE;'>#Virol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18450, encryptionId=cb141845040, topicName=Virol)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/FGFAawy0kQNXbuvUuLtUVrx5aKhOIkwqJwyxu0QlpLFIDSb1Ht19ptXvYBjuAoNBubibnNF3iazdpico7gJlbBVQg/132, createdBy=edaf2500125, createdName=ms3892185887221420, createdTime=Tue Jul 09 10:44:00 CST 2019, time=2019-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418024, encodeId=78e1141802477, content=<a href='/topic/show?id=6ba485016cd' target=_blank style='color:#2F92EE;'>#脑肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85016, encryptionId=6ba485016cd, topicName=脑肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f03326658, createdName=839640779, createdTime=Thu Aug 09 03:44:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337048, encodeId=8f4033e048d6, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Tue Aug 07 12:49:38 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-09 839640779

    #脑肿瘤#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2077381, encodeId=b02720e738190, content=<a href='/topic/show?id=cb141845040' target=_blank style='color:#2F92EE;'>#Virol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18450, encryptionId=cb141845040, topicName=Virol)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/FGFAawy0kQNXbuvUuLtUVrx5aKhOIkwqJwyxu0QlpLFIDSb1Ht19ptXvYBjuAoNBubibnNF3iazdpico7gJlbBVQg/132, createdBy=edaf2500125, createdName=ms3892185887221420, createdTime=Tue Jul 09 10:44:00 CST 2019, time=2019-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418024, encodeId=78e1141802477, content=<a href='/topic/show?id=6ba485016cd' target=_blank style='color:#2F92EE;'>#脑肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85016, encryptionId=6ba485016cd, topicName=脑肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f03326658, createdName=839640779, createdTime=Thu Aug 09 03:44:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337048, encodeId=8f4033e048d6, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Tue Aug 07 12:49:38 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 lietome2

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

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