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Int J Oncol:PPI或可有效治疗前列腺癌

2018-07-02 MedSci MedSci原创

Polyphyllin I(PPI)是一种天然化合物,从巴黎鸢尾根茎中提取,用于治疗发烧和头痛。在本研究中,研究人员评估了PPI在前列腺癌(PC)细胞中的抗肿瘤活性。在低剂量下,PPI可降低PC细胞的增殖、侵袭和上皮-间充质转化(EMT)。PPI降低了对肿瘤转移至关重要的基质金属蛋白酶7(MMP7)的表达,还降低了与EMT相关的因素Snail和波形蛋白的表达。此外,PPI抑制AP-1转录活性以及A

Polyphyllin I(PPI)是一种天然化合物,从巴黎鸢尾根茎中提取,用于治疗发烧和头痛。在本研究中,研究人员评估了PPI在前列腺癌(PC)细胞中的抗肿瘤活性。

在低剂量下,PPI可降低PC细胞的增殖、侵袭和上皮-间充质转化(EMT)。PPI降低了对肿瘤转移至关重要的基质金属蛋白酶7(MMP7)的表达,还降低了与EMT相关的因素Snail和波形蛋白的表达。此外,PPI抑制AP-1转录活性以及AP-1与MMP7和波形蛋白启动子的结合。

结果表明,PPI下调胞外信号相关激酶(ERK)的磷酸化,ERK是AP-1的上游调节剂。PPI可能通过抑制蛋白磷酸酶2A(CIP2A)/蛋白磷酸酶2A(PP2A)/ERK轴抑制剂,下调MMP7、vimentin和Snail的表达,抑制肿瘤侵袭和EMT。PC异种移植小鼠模型中发现,PPI可降低肿瘤生长和体重。此外,PPI还可抑制PPI治疗的肿瘤中的增殖细胞核抗原表达和CIP2A/PP2A/ERK信号传导通路。

综上所述,本研究的结果表明,PPI可通过抑制CIP2A/PP2A/ERK信号轴来抑制PC细胞的生长、侵袭和EMT。因此,PPI或可用于治疗PC。

原始出处:


Liu X, Sun Z, et al., Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer. Int J Oncol. 2018 Jun 29. doi: 10.3892/ijo.2018.4464.

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    2019-02-22 minlingfeng
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    2018-07-03 kafei

    学习了谢谢

    0

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    2018-07-03 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

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    2018-07-03 yjs木玉

    好好好好好好好好

    0

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    2018-07-03 phoebeyan520

    学习了.谢谢分享

    0

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    2018-07-03 飛歌

    厉害了我的哥

    0

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