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上海学者称,冠脉硬化患者会先出现心脏舒张功能降低

2018-12-06 朱柳媛 中国循环杂志

上海市奉贤区中心医院心内科张琼、马江伟等人通过超声心动图和左心室造影检查发现,冠状动脉粥样硬化患者在没有心脏收缩功能改变时,心脏舒张功能就已明显减低。而且,冠状动脉狭窄程度与冠状动脉舒张功能减低明显相关。


上海市奉贤区中心医院心内科张琼、马江伟等人通过超声心动图和左心室造影检查发现,冠状动脉粥样硬化患者在没有心脏收缩功能改变时,心脏舒张功能就已明显减低。而且,冠状动脉狭窄程度与冠状动脉舒张功能减低明显相关。

研究随机选取2014-09 至2017-08 疑诊为冠心病并行冠状动脉造影(CAG) 的患者600 例,根据冠状动脉狭窄程度分为:对照组(无狭窄)150 例,冠状动脉粥样硬化组(狭窄<50%)150 例,冠心病组(狭窄≥ 50%)300 例。

研究结果显示,与对照组比,冠状动脉粥样硬化组和冠心病组的左心室舒张末期容积、左心房容积指数、左心室舒张时间常数均较高(P 均<0.05)。

冠状动脉粥样硬化组和冠心病组的左心室舒张早期快速充盈的充盈峰/左心室舒张晚期快速充盈的充盈峰值(E/A)、左心室压力上升最大速度、左心室压力下降最大速度、舒张期前1/3 充盈分数、舒张期后1/3 充盈分数均较降低,冠心病组的左心室射血分数较低。三组间两两比较,E/A<1.2 的患者比例均有显著差异。

多因素Logistic回归分析显示:Gensini 评分是心脏舒张功能减退的独立危险因素(OR=1.93,95%CI:1.31~2.68,P=0.01)。

与对照组比,冠状动脉粥样硬化组和冠心病组的冠状动脉舒张末期容积(CEDV)、冠状动脉收缩末期容积(CESV)、冠状动脉压力下降最大速度(C-dp/dtmax)、冠状动脉压力上升最大速度(C+dp/dtmax)均较低;与冠状动脉硬化组比,冠心病组的CEDV、CESV、C-dp/dtmax、C+dp/dtmax 均较低。

Spearman 相关性分析显示:Gensini 评分与C-dp/dtmax 呈负相关(r =-0.43,P<0.01)。

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    2018-12-12 yahu
  2. [GetPortalCommentsPageByObjectIdResponse(id=2026160, encodeId=49262026160f9, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Dec 12 05:51:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355704, encodeId=1e6a355e04d4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Dec 18 05:59:17 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354663, encodeId=90a7354663e3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Dec 06 20:53:43 CST 2018, time=2018-12-06, status=1, ipAttribution=)]
    2018-12-18 ren1mw

    学习一下

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2026160, encodeId=49262026160f9, content=<a href='/topic/show?id=c2968658593' target=_blank style='color:#2F92EE;'>#舒张功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86585, encryptionId=c2968658593, topicName=舒张功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Dec 12 05:51:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355704, encodeId=1e6a355e04d4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Dec 18 05:59:17 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354663, encodeId=90a7354663e3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Dec 06 20:53:43 CST 2018, time=2018-12-06, status=1, ipAttribution=)]
    2018-12-06 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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