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Fertil Steril:PLCz蛋白质有望提高受精几率

2012-09-27 黄堃 新华社

对于部分不育男性来说,导致其生育问题的原因是精子中缺少一种名为PLCz的蛋白质。英国的一个研究团队宣布,其成员已能在实验室中制造这种蛋白质,如果把它添加到精子中,就有望提高卵子受精的几率。 来自英国加的夫大学等机构的研究人员在新一期美国期刊《生育与不孕》(Fertility and Sterility)上报告说,精子在使卵子受精的过程中会向卵子注入一种名为PLCz的蛋白质,它会引发受精卵发育所必

对于部分不育男性来说,导致其生育问题的原因是精子中缺少一种名为PLCz的蛋白质。英国的一个研究团队宣布,其成员已能在实验室中制造这种蛋白质,如果把它添加到精子中,就有望提高卵子受精的几率。

来自英国加的夫大学等机构的研究人员在新一期美国期刊《生育与不孕》(Fertility and Sterility)上报告说,精子在使卵子受精的过程中会向卵子注入一种名为PLCz的蛋白质,它会引发受精卵发育所必需的一系列生理反应。有些男性之所以不育,是因为精子中缺少这种蛋白质,导致精子即便与卵子结合,也无法进一步发育成胚胎。

研究人员在实验室中成功制造了具有活性的PLCz蛋白质。实验显示,如果将它注入未受精的卵子中,卵子会出现与正常受精过程中相同的一系列生理反应,这说明如果给存在相应缺陷的精子添加这种蛋白质,就有望大大提高卵子受精的几率。

doi:10.1016/j.fertnstert.2012.07.556
PMC:

PMID:

Influence of human sperm motility and cryopreservation on the oocyte activating factor phospholipase C zetaB. Heindryck

D. Nikiforaki, F. Vanden Meerschaut, W. De Vos, S. Lierman, P. De Sutter

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