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JAMA Neurol:胖女人小心了,口服避孕药脑静脉血栓形成风险大

2016-03-15 Mechront 译 MedSci原创

近期发表在JAMA Neurology的研究称,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,脑静脉血栓形成(CVT)的风险更大。CVT是一种罕见的疾病,主要影响年轻的成年人和儿童。CVT与静脉血栓栓塞症(VTE)有相同的危险因素如癌症和口服避孕药,此外CVT还有特定的危险因素如局部感染和头部外伤。荷兰阿姆斯特丹学术医疗中心的Jonathan M. Coutinho博士对来自两家医院的

近期发表在JAMA Neurology的研究称,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,脑静脉血栓形成(CVT)的风险更大。

CVT是一种罕见的疾病,主要影响年轻的成年人和儿童。CVT与静脉血栓栓塞症(VTE)有相同的危险因素如癌症和口服避孕药,此外CVT还有特定的危险因素如局部感染和头部外伤。

荷兰阿姆斯特丹学术医疗中心的Jonathan M. Coutinho博士对来自两家医院的CVT患者进行了一项研究,纳入了186例CVT和6,134例对照组。研究者发现,与对照组相比,CVT患者有以下特征:更年轻(40 vs. 48岁)、女性、口服避孕药频率更高、更有可能有癌症既往史。

研究者指出,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,CVT风险增加近30倍!口服避孕药的超重女性CVT风险同样增加。不过没有使用口服避孕药肥胖人群无论男女,对CVT风险不会产生影响。

由于样本量小,导致了本研究的限制。

作者总结说:“口服避孕药的肥胖女性VTE和CVT的风险如此之高,可能会导致临床医生不愿开具口服避孕药处方给肥胖人群。不过,虽然潜在的相对风险增加了,但是CVT的绝对风险仍很低。不过,口服避孕药会增加意外怀孕风险,进而增加妊娠相关血栓事件的风险。临床上应告知口服避孕药的肥胖人群,其血栓形成风险会增高,尤其是还存在其他危险因素的情况下。这类女性可以选择与血栓形成无关的其他避孕方式如宫内节育器,以避免风险的增加。”

原始出处:

Susanna M. Zuurbier MD, Marcel Arnold MD, PhD,et al.Risk of Cerebral Venous Thrombosis in Obese Women.JAMA Neurology, doi:10.1001/jamaneurol.2016.0001, published online 14 March 2016.


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    2016-04-25 yinhl1978
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    2016-11-12 fusion
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    2016-03-21 1de304d2m86(暂无匿称)

    科学减肥

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999660, encodeId=f2f0199966041, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 25 05:57:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955232, encodeId=9b1319552327e, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 17 15:57:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697302, encodeId=4d92169e3022d, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Nov 12 22:57:00 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72115, encodeId=499be211538, content=科学减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:32:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71514, encodeId=f309e1514c4, content=口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Mar 18 12:50:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483240, encodeId=e5111483240ed, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582139, encodeId=c1e31582139dd, content=<a href='/topic/show?id=4fe43824210' target=_blank style='color:#2F92EE;'>#口服避孕药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38242, encryptionId=4fe43824210, topicName=口服避孕药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da1416890157, createdName=654699882_84926991, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69621, encodeId=35516962114, content=瘦,很重要呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Wed Mar 16 13:18:00 CST 2016, time=2016-03-16, status=1, ipAttribution=)]
    2016-03-18 Lisa971

    口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999660, encodeId=f2f0199966041, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 25 05:57:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955232, encodeId=9b1319552327e, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 17 15:57:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697302, encodeId=4d92169e3022d, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Nov 12 22:57:00 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72115, encodeId=499be211538, content=科学减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:32:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71514, encodeId=f309e1514c4, content=口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Mar 18 12:50:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483240, encodeId=e5111483240ed, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582139, encodeId=c1e31582139dd, content=<a href='/topic/show?id=4fe43824210' target=_blank style='color:#2F92EE;'>#口服避孕药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38242, encryptionId=4fe43824210, topicName=口服避孕药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da1416890157, createdName=654699882_84926991, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69621, encodeId=35516962114, content=瘦,很重要呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Wed Mar 16 13:18:00 CST 2016, time=2016-03-16, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1999660, encodeId=f2f0199966041, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 25 05:57:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955232, encodeId=9b1319552327e, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 17 15:57:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697302, encodeId=4d92169e3022d, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Nov 12 22:57:00 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72115, encodeId=499be211538, content=科学减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:32:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71514, encodeId=f309e1514c4, content=口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Mar 18 12:50:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483240, encodeId=e5111483240ed, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582139, encodeId=c1e31582139dd, content=<a href='/topic/show?id=4fe43824210' target=_blank style='color:#2F92EE;'>#口服避孕药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38242, encryptionId=4fe43824210, topicName=口服避孕药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da1416890157, createdName=654699882_84926991, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69621, encodeId=35516962114, content=瘦,很重要呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Wed Mar 16 13:18:00 CST 2016, time=2016-03-16, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1999660, encodeId=f2f0199966041, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 25 05:57:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955232, encodeId=9b1319552327e, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 17 15:57:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697302, encodeId=4d92169e3022d, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Nov 12 22:57:00 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72115, encodeId=499be211538, content=科学减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:32:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71514, encodeId=f309e1514c4, content=口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Mar 18 12:50:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483240, encodeId=e5111483240ed, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582139, encodeId=c1e31582139dd, content=<a href='/topic/show?id=4fe43824210' target=_blank style='color:#2F92EE;'>#口服避孕药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38242, encryptionId=4fe43824210, topicName=口服避孕药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da1416890157, createdName=654699882_84926991, createdTime=Thu Mar 17 10:57:00 CST 2016, time=2016-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69621, encodeId=35516962114, content=瘦,很重要呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9a01693879, createdName=任然, createdTime=Wed Mar 16 13:18:00 CST 2016, time=2016-03-16, status=1, ipAttribution=)]
    2016-03-16 任然

    瘦,很重要呀

    0

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