DIABETOLOGIA：Toll样受体9在1型糖尿病的小鼠模型中负调节胰岛β细胞生长和功能

2018-12-23 MedSci MedSci原创

先天免疫效应因子与环境相互作用，参与自身免疫性疾病1型糖尿病的发病机制。虽然最近的研究表明先天免疫Toll样受体（TLRs）参与组织发育，但与自身免疫相比，TLR在组织发育中的作用知之甚少。本研究旨在通过使用NOD小鼠研究TLR9在1型糖尿病中胰岛β细胞的发育和功能中的作用。研究人员通过建立Tlr9 - / - NOD小鼠模型并研究它们的1型糖尿病发展和β细胞功能，包括

先天免疫效应因子与环境相互作用，参与自身免疫性疾病1型糖尿病的发病机制。虽然最近的研究表明先天免疫Toll样受体（TLRs）参与组织发育，但与自身免疫相比，TLR在组织发育中的作用知之甚少。本研究旨在通过使用NOD小鼠研究TLR9在1型糖尿病中胰岛β细胞的发育和功能中的作用。

研究人员通过建立Tlr9 ^{- / -} NOD小鼠模型并研究它们的1型糖尿病发展和β细胞功能，包括胰岛素分泌和葡萄糖耐量。评估胰岛和β细胞数量，并通过流式细胞术分析β细胞上的CD140a表达。此外，还测试了Tlr9 ^{- / -} C57BL / 6小鼠中的β细胞功能。最后，我们使用TLR9拮抗剂阻断野生型NOD小鼠中的TLR9信号传导，以验证TLR9在β细胞发育和功能中的作用。

结果显示，TLR9缺乏促进胰岛发育和β细胞分化，导致葡萄糖耐量增加，胰岛素敏感性改善和第一期胰岛素分泌反应增强。这部分是由CD140a（也称为血小板衍生生长因子受体-α[PDGFRα]）的上调所介导的。在没有TLR9的情况下，通过遗传靶向或用TLR9拮抗剂处理诱导，其对β细胞的发生和功能具有相似的作用，NOD小鼠可以预防糖尿病。

本研究的意义在于将TLR9和CD140a途径与调节胰岛β细胞发育和功能联系起来，并指出了糖尿病预防和/或治疗的潜在治疗靶点。

原始出处：

Mengju Liu, Jian Peng, Ningwen Tai,Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes

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2019-02-16 一闲

#胰岛β细胞#

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2019-08-09 ms5439512287675881

#BET#

69 0
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2019-11-26 baoya

#胰岛#

67 0
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2019-10-28 ms9608593228839890

#DIA#

70 0
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2018-12-25 zhouqu_8

#小鼠模型#

71 0
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2018-12-25 wwzzly

#细胞生长#

97 0
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2018-12-25 ms24272190615788285182

#β细胞#

110 0
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2018-12-23 misszhang

谢谢MedSci提供最新的资讯

77 0
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2018-12-23 CHANGE

梅斯里提供了很多疾病的模型计算公式，赞一个！

62 0

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