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AP&T:慢性乙型肝炎患者队列中的疾病合并症随时间增加

2020-07-06 MedSci原创 MedSci原创

慢性乙型肝炎(CHB)患者是否比非CHB患者有更多的非肝脏合并症存在争议。为了表征韩国CHB患者的人口统计学,合并症和健康利用情况,本项研究对合格患者进行了相关研究。

背景

慢性乙型肝炎(CHB)患者是否比非CHB患者有更多的非肝脏合并症存在争议。为了表征韩国CHB患者的人口统计学,合并症和健康利用情况,本项研究对合格患者进行了相关研究。

 

方法

研究人员使用韩国健康保险审查与评估服务(HIRA)2007-2016数据库,对患有CHB的成年患者进行分析。CHB病例和非CHB对照者使用倾向得分匹配方法以1:4的比例匹配。

 

结果

CHB患者的年龄从2007年的平均46.9岁显着增加到2016年的52.3岁。与相匹配的对照组相比,CHB患者中有肝相关和非肝相关合并症的人的比例更高(血脂异常[37.23%vs 23.77%,P<0.0001],高血压[29.39%vs 25.27%,P<0.0001],慢性肾脏病(CKD)[3.02%vs 1.14%,P<0.0001]和骨质疏松/骨折[OF] [4.09%vs 3.23% ,P<0.0001])。大约50%的CHB患者在CKD,糖尿病,DLP和OF中合并症多于一种。调整混杂因素后,CHB患者中CKD的机率比匹配对照组高1.42倍,CHB患者中骨折的机率比对照高1.09倍(P <0.0001)。

 

结论

CHB患者的肝脏以及非肝合并症的患病率高于对照组,并且随时间增加。

原始出处:

Hyunwoo Oh. et al. Increasing comorbidities in a South Korea insured population‐based cohort of patients with chronic hepatitis B. Alimentary Pharmacology and Therapeutics.2020.

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