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Slas Discovery:骨关节炎疼痛的新治疗靶点

2017-08-28 佚名 medicalxpress

DavidA.Walsh和JoanneStocks在2017年9月发行的SLASDiscovery(以前的“生物分子筛选杂志”)的新评论中探讨了骨骼肌炎(OA)疼痛的不断发展的治疗方法和未来疗法。



DavidA.Walsh和JoanneStocks在2017年9月发行的SLASDiscovery(以前的“生物分子筛选杂志”)的新评论中探讨了骨骼肌炎(OA)疼痛的不断发展的治疗方法和未来疗法。

它涵盖了现有治疗的局限性,并介绍了对骨骼肌炎(OA)疼痛背后复杂机制的最新理解,为临床治疗提供了令人兴奋的新可能性和潜在的新治疗目标。最近的专利注册表明,未来骨骼肌炎(OA)疗法的领域可以靶向炎症,骨骼和软骨;感觉神经组织工程和膳食补充剂。

讨论的两个新的深入研究领域是使用组合疗法和生物标志物的发展来有针对性的治疗疼痛。由于该疾病的多种机制,单独的药物疗法可能不起作用,而需要结合心理和物理治疗方法。探索成像,遗传或湿生物标志物预测疼痛和分层最有可能受益于特定治疗的患者的潜力。结合不同学科边界的生物标志物可能会增加其在预测治疗需求或结果方面的价值。

通过增加对骨骼肌炎(OA)疼痛基础机制的了解,新药也可能来源于为其他疾病开发的药物,以及针对关节特异性疼痛机制的新型化合物。

骨骼肌炎(OA)是关节炎的最常见形式,但不幸的是,目前可用于改善生活质量的最有效的治疗方法是全面关节置换术。

原始出处:

DA Walsh, J Stocks. New Therapeutic Targets for Osteoarthritis Pain. Slas Discovery 2017

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    2018-03-22 yahu
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    2018-04-26 cmj8wellington
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    2017-11-03 lisa438
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    2017-08-30 lmm397
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    2017-08-30 仁者大医

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