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Circulation:裸金属支架植入术后,男性比女性风险大

2015-10-27 崔倩 译 MedSci原创

据报道,女性在裸金属支架(BMS)植入后中期再狭窄和再次血运重建的风险较低。然而,性别对于BMS植入后的长期影响还没有被报道。在多中心CREDO-Kyoto表队列-1研究的9877例患者中,5313例患者进行了BMS植入术(男性:n=3742,女性:n=1571)。4515例(85.0%)患者在10年时完成了后续随访(持续时间:10.3±3.1 [0.0-14.1]年)。靶病变血运重建的累计发生率

据报道,女性在裸金属支架(BMS)植入后,中期再狭窄和再次血运重建的风险较低。然而,性别对于BMS植入后的长期影响还没有被报道。

在多中心CREDO-Kyoto表队列-1研究的9877例患者中,5313例患者进行了BMS植入术(男性:n=3742,女性:n=1571)。4515例(85.0%)患者在10年时完成了后续随访(持续时间:10.3±3.1 [0.0-14.1]年)。靶病变血运重建的累计发生率(TLR)在1年时为27%,10年时为34%(超过1年0.8%/年)。非靶病变血运重建(非TLR)的累计发生率超出1年时主要是冠状动脉血运重建(在1年时为13%,在10年时为31%[2.0%/年,超过1年])。支架血栓(ST)的累计发生率很低(在1年时为1.2%,在10年时为1.9%)。年龄较大的女性的心血管危险因素比男性更为普遍。男性的累积10年发病率和风险调整后的TLR显著高于女性(36% vs 30%,P<0.001,调整后的HR 1.29 [95%Cl 1.15-1.46],P<0.001)。不论年龄,男性相对于女性的TLR,依然存在较高的风险(<75岁,和≥75岁)。与女性相比,男性的也有显著较高的调整后的全因死亡、心肌梗死(MI)、卒中、CABG、TLR和非TLR风险。

TLR和ST持续到发生无衰减至BMS植入10年后。与女性相比,男性均与较高的调整后10年的全因死亡、心肌梗死、卒中、CABG、TLR和非TLR风险相关。

原始出处:

Kyohei Yamaji,Hiroki Shiomi,Takeshi Morimoto,et al.Influence of Gender on Long-Term Outcomes After Implantation of Bare-Metal Stent,Circulation,2015.10.6

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    2016-06-28 gous
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    2015-10-29 jiyangfei
  5. [GetPortalCommentsPageByObjectIdResponse(id=1935143, encodeId=54a8193514325, content=<a href='/topic/show?id=49455e1086e' target=_blank style='color:#2F92EE;'>#支架植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57108, encryptionId=49455e1086e, topicName=支架植入)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri May 27 18:14:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926570, encodeId=154c19265e039, content=<a href='/topic/show?id=4c19961e039' target=_blank style='color:#2F92EE;'>#金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96170, encryptionId=4c19961e039, topicName=金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Tue Jun 28 20:14:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990193, encodeId=95241990193a9, content=<a href='/topic/show?id=94fc9043603' target=_blank style='color:#2F92EE;'>#裸金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90436, encryptionId=94fc9043603, topicName=裸金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Sep 09 21:14:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520279, encodeId=cb7e15202e9b5, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591176, encodeId=f50215911e637, content=<a href='/topic/show?id=2e1e5e109a9' target=_blank style='color:#2F92EE;'>#支架植入术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57109, encryptionId=2e1e5e109a9, topicName=支架植入术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8c817920738, createdName=amy0556, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41843, encodeId=345341843e5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150830/IMG55E294026A9942981.jpg, createdBy=fa351627501, createdName=惜言, createdTime=Thu Oct 29 00:46:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41832, encodeId=0a1b41832be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Wed Oct 28 23:42:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1935143, encodeId=54a8193514325, content=<a href='/topic/show?id=49455e1086e' target=_blank style='color:#2F92EE;'>#支架植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57108, encryptionId=49455e1086e, topicName=支架植入)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri May 27 18:14:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926570, encodeId=154c19265e039, content=<a href='/topic/show?id=4c19961e039' target=_blank style='color:#2F92EE;'>#金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96170, encryptionId=4c19961e039, topicName=金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Tue Jun 28 20:14:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990193, encodeId=95241990193a9, content=<a href='/topic/show?id=94fc9043603' target=_blank style='color:#2F92EE;'>#裸金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90436, encryptionId=94fc9043603, topicName=裸金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Sep 09 21:14:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520279, encodeId=cb7e15202e9b5, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591176, encodeId=f50215911e637, content=<a href='/topic/show?id=2e1e5e109a9' target=_blank style='color:#2F92EE;'>#支架植入术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57109, encryptionId=2e1e5e109a9, topicName=支架植入术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8c817920738, createdName=amy0556, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41843, encodeId=345341843e5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150830/IMG55E294026A9942981.jpg, createdBy=fa351627501, createdName=惜言, createdTime=Thu Oct 29 00:46:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41832, encodeId=0a1b41832be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Wed Oct 28 23:42:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
    2015-10-29 惜言

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1935143, encodeId=54a8193514325, content=<a href='/topic/show?id=49455e1086e' target=_blank style='color:#2F92EE;'>#支架植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57108, encryptionId=49455e1086e, topicName=支架植入)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri May 27 18:14:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926570, encodeId=154c19265e039, content=<a href='/topic/show?id=4c19961e039' target=_blank style='color:#2F92EE;'>#金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96170, encryptionId=4c19961e039, topicName=金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Tue Jun 28 20:14:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990193, encodeId=95241990193a9, content=<a href='/topic/show?id=94fc9043603' target=_blank style='color:#2F92EE;'>#裸金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90436, encryptionId=94fc9043603, topicName=裸金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Sep 09 21:14:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520279, encodeId=cb7e15202e9b5, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591176, encodeId=f50215911e637, content=<a href='/topic/show?id=2e1e5e109a9' target=_blank style='color:#2F92EE;'>#支架植入术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57109, encryptionId=2e1e5e109a9, topicName=支架植入术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8c817920738, createdName=amy0556, createdTime=Thu Oct 29 13:14:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41843, encodeId=345341843e5, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150830/IMG55E294026A9942981.jpg, createdBy=fa351627501, createdName=惜言, createdTime=Thu Oct 29 00:46:00 CST 2015, time=2015-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41832, encodeId=0a1b41832be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Wed Oct 28 23:42:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
    2015-10-28 sanshengshi

    0

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