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Front Mol Neurosci：测序分析确定参与神经损伤后神经性疼痛ncRNA的脊髓表达谱

2017-09-15 MedSci MedSci原创

关注

神经病理性疼痛（NP）是由神经系统的损伤引起的，导致痛觉异常，这与感觉通路中基因表达的变化有关。然而，其分子机制尚未完全理解。非编码核糖核酸（ncRNA）是一种RNA分子，不翻译成蛋白质，参与了许多细胞过程，而其突变或失衡可引起多种疾病。尽管研究已经发现ncRNA在NP的发病中发挥作用，但是其具体作用尚不清楚。在这项研究中，研究人员进行了测序分析以探究坐骨神经损伤诱导的NP患者中脊髓ncRNA的表

神经病理性疼痛（NP）是由神经系统的损伤引起的，导致痛觉异常，这与感觉通路中基因表达的变化有关。然而，其分子机制尚未完全理解。非编码核糖核酸（ncRNA）是一种RNA分子，不翻译成蛋白质，参与了许多细胞过程，而其突变或失衡可引起多种疾病。尽管研究已经发现ncRNA在NP的发病中发挥作用，但是其具体作用尚不清楚。

在这项研究中，研究人员进行了测序分析以探究坐骨神经损伤诱导的NP患者中脊髓ncRNA的表达模式。结果显示坐骨神经损伤（SNI）术后14天共有134个lncRNA，12个miRNAs，188个circRNAs和1066个mRNAs明显发生变化。接着，实时定量聚合酶链反应（PCR）验证选定的lncRNAs，miRNAs，circrnas和mRNA。使用生物信息学工具和数据库来发掘潜在的ncRNA功能和相互关系。

结果数据表明，在SNI发病机制中的最重要参与途径是核糖体，PI3K-Akt信号通路、粘着、ECM受体相互作用、阿米巴病和蛋白质的消化和吸收。此外，研究人员还构建了NP的lncRNA-miRNA-mRNA和circRNA-miRNA-mRNA网络。

总之，该研究首次全面确定了脊髓中调控ncRNAs并说明了NP发病机制中不同的ncRNA表达模式。这些研究结果有助于进一步探究NP的发病机制，并促进研发靶向ncRNAs的新的NP治疗方法。

原始出处：

Jun Zhou, Qingming Xiong,et al., Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. Front Mol Neurosci. 2017; 10: 91. Published online 2017 Apr 3. doi: 10.3389/fnmol.2017.00091.

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    2018-05-09 yanjie6253_56072842

    #CRN#

    0

  2. 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createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-12-10 hywen7326

    #神经性#

    0

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createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 老神经

    厉害.为啥您就这么有才

    0

  4. 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createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 狼毒花1982

    学习了感谢分享

    0

  5. 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    2017-09-17 lsndxfj

    #ROS#

    0

  6. 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createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 tm10051981

    #神经性疼痛#

    0

  7. 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createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584277, encodeId=4c4415842e71c, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244770, encodeId=da48244e702b, content=不错的文章.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 ms3046638856685384

    #损伤#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2005642, encodeId=a322200564224, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed May 09 19:49:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035416, encodeId=89d82035416da, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Sun Dec 10 06:49:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245090, encodeId=3c6b2450905b, content=厉害.为啥您就这么有才, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/19/0ebaf0cf0d5ff01d405c93410e1ad19c.jpg, createdBy=04c51766225, createdName=老神经, createdTime=Sun Sep 17 21:19:20 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245077, encodeId=c4fd2450e75d, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Sep 17 20:25:50 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364233, encodeId=7daf136423306, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372912, encodeId=c68413e291216, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397322, encodeId=39c0139e322b8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584277, encodeId=4c4415842e71c, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244770, encodeId=da48244e702b, content=不错的文章.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 LShY0906_98743849

    #神经损伤#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2005642, encodeId=a322200564224, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed May 09 19:49:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035416, encodeId=89d82035416da, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Sun Dec 10 06:49:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245090, encodeId=3c6b2450905b, content=厉害.为啥您就这么有才, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/19/0ebaf0cf0d5ff01d405c93410e1ad19c.jpg, createdBy=04c51766225, createdName=老神经, createdTime=Sun Sep 17 21:19:20 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245077, encodeId=c4fd2450e75d, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Sep 17 20:25:50 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364233, encodeId=7daf136423306, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372912, encodeId=c68413e291216, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397322, encodeId=39c0139e322b8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584277, encodeId=4c4415842e71c, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244770, encodeId=da48244e702b, content=不错的文章.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-16 131****2916

    不错的文章.值得学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2005642, encodeId=a322200564224, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed May 09 19:49:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035416, encodeId=89d82035416da, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Sun Dec 10 06:49:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245090, encodeId=3c6b2450905b, content=厉害.为啥您就这么有才, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/19/0ebaf0cf0d5ff01d405c93410e1ad19c.jpg, createdBy=04c51766225, createdName=老神经, createdTime=Sun Sep 17 21:19:20 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245077, encodeId=c4fd2450e75d, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Sep 17 20:25:50 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364233, encodeId=7daf136423306, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372912, encodeId=c68413e291216, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397322, encodeId=39c0139e322b8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584277, encodeId=4c4415842e71c, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Sep 17 12:49:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244770, encodeId=da48244e702b, content=不错的文章.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Sep 16 23:34:13 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244545, encodeId=d1a92445452d, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sat Sep 16 08:52:40 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-16 戒馋，懒，贪

    谢谢分享.学习了

    0

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