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Cell子刊:探究致癌基因新功能

2014-03-31 佚名 生物通

来自乔治亚大学的发育生物学家们发现了一种称作为MGA(Max's Giant Associated protein)的特异基因的一些新功能。这一尚未受到研究者重视的蛋白似乎控制了许多的发育过程,也有可能与癌症形成相关。研究人员将他们的研究结果详细描述在《发育细胞》(Developmental Cell)杂志上。 该研究的课题负责人、乔治亚大学著名癌症科学家Scott Dougan说:“在

来自乔治亚大学的发育生物学家们发现了一种称作为MGA(Max's Giant Associated protein)的特异基因的一些新功能。这一尚未受到研究者重视的蛋白似乎控制了许多的发育过程,也有可能与癌症形成相关。研究人员将他们的研究结果详细描述在《发育细胞》(Developmental Cell)杂志上。


该研究的课题负责人、乔治亚大学著名癌症科学家Scott Dougan说:“在胚胎发育过程中参与人体构建的基因在生命的晚期也可以突变,导致癌症。没有人针对MGA开展过系统的研究,但现在有一些研究将它与癌症关联起来,我们对此抱有极大的兴趣。”

与MGA相关的最常见癌症是慢性淋巴细胞白血病,这是一种因机体生成太多的白细胞而导致的血液和骨髓疾病。初期测试表明,当MGA无法成功控制另一种促成癌症生长的蛋白MYC的活性时,就有可能形成这种癌症。

Dougan和他的研究小组利用自己的方法改变了斑马鱼胚胎中的MGA水平,想看看他们是否能够发现MGA的其他作用。

他们发现,MGA还帮助控制了负责胚胎中骨发育的蛋白BMP表达。但在成体内,BMP活性改变可以导致肿瘤形成,MGA有可能是这一有害转变的一个组成部分。

Dougan说:“科学家们还只是刚开始了解MGA蛋白所起的作用,但我们测试表明MGA或许控制了比最初认为的更多的过程。MGA有可能与一些其他的癌症有关,在确定之前我们需要展开更多的研究。”

在接下来的几个月里,Dougan和他的研究小组计划进一步探究MGA的作用,以确定它何时控制MYC,何时控制BMP,以及如何参与肿瘤形成的。

Dougan说:“这是基础科学,我们需要这样的研究来了解我们的生物学基础。一旦我们获得这一认识,我们就可以开始开发出一些新的疗法以新的、更有效的方式来治疗疾病。”

原始出处:

Sun Y1, Tseng WC1, Fan X1, Ball R1, Dougan ST2.Extraembryonic signals under the control of MGA, Max, and Smad4 are required for dorsoventral patterning.Dev Cell. 2014 Feb 10;28(3):322-34. doi: 10.1016/j.devcel.2014.01.003.

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    2014-07-03 维他命
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    2014-04-02 jambiya
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