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NEJM:维生素E醋酸酯或与电子烟相关肺损伤相关

2019-12-23 MedSci MedSci原创

研究认为,几乎所有的电子烟相关肺损伤患者支气管肺泡灌洗液中均发现维生素E醋酸酯,或与EVALI发病有关

目前,因电子烟相关肺损伤(EVALI)的原因尚未确定,EVALI患者支气管肺泡灌洗(BAL)液中毒物的检测是了解疾病病因的重要方法。

近日,研究人员收集了51名EVALI患者和99名健康参与者BAL洗液,采用同位素稀释质谱法测定几种主要毒物:维生素E醋酸酯、植物油、中链甘油三酯油、椰子油、石油馏分油和稀释剂萜烯。

51名患者中,25例为确诊病例,26例极有可能为EVALI病例。所有患者中,48例(94%)的BAL液中发现了维生素E醋酸酯,而健康对照组的BAL液中未检出维生素E乙酸酯。各组均发现1例椰子油和柠檬烯,未发现其他毒物。在有实验室或流行病学数据的病例中,50人中有47人(94%)在BAL液中检测到四氢大麻酚(THC)或其代谢物,47例患者中有30例(64%)检测到尼古丁及其代谢物。

研究认为,几乎所有的电子烟相关肺损伤患者支气管肺泡灌洗液中均发现维生素E醋酸酯,或与EVALI发病有关。

原始出处:

Benjamin C. Blount et al. Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. N Engl J Med, December 20, 2019.

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    2019-12-25 tastas
  5. [GetPortalCommentsPageByObjectIdResponse(id=2082272, encodeId=7ea020822e289, content=<a href='/topic/show?id=5ca5e908224' target=_blank style='color:#2F92EE;'>#维生素E醋酸酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79082, encryptionId=5ca5e908224, topicName=维生素E醋酸酯)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Mon Feb 17 22:08:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397883, encodeId=9f6a139e8831f, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419850, encodeId=a26e1419850c8, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503322, encodeId=2e33150332208, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569951, encodeId=e79115699514a, content=<a href='/topic/show?id=5f24e007361' target=_blank style='color:#2F92EE;'>#电子烟相关肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70073, encryptionId=5f24e007361, topicName=电子烟相关肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841d15610664, createdName=lhlxtx, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035059, encodeId=ed21103505935, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Dec 23 21:08:00 CST 2019, time=2019-12-23, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2082272, encodeId=7ea020822e289, content=<a href='/topic/show?id=5ca5e908224' target=_blank style='color:#2F92EE;'>#维生素E醋酸酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79082, encryptionId=5ca5e908224, topicName=维生素E醋酸酯)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Mon Feb 17 22:08:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397883, encodeId=9f6a139e8831f, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419850, encodeId=a26e1419850c8, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503322, encodeId=2e33150332208, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569951, encodeId=e79115699514a, content=<a href='/topic/show?id=5f24e007361' target=_blank style='color:#2F92EE;'>#电子烟相关肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70073, encryptionId=5f24e007361, topicName=电子烟相关肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841d15610664, createdName=lhlxtx, createdTime=Wed Dec 25 09:08:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035059, encodeId=ed21103505935, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Dec 23 21:08:00 CST 2019, time=2019-12-23, status=1, ipAttribution=)]
    2019-12-23 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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