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Radiology:精神分裂症患者灰质在减少

2018-02-18 shaosai MedSci原创

本研究旨在验证精神分裂症患者结构变化的空间及因果关系,并将结果发表在radiology上。

本研究旨在验证精神分裂症患者结构变化的空间及因果关系,并将结果发表在radiology上。

本研究共纳入了97例精神分裂症患者(女性29例,平均年龄41岁 ± 11.5;范围16-66 岁; 病程16.3 岁 ± 10.9; 范围0-50 岁)及126例性别和年龄匹配的健康志愿者(38岁±14.9;范围18-68岁; 女性42例)。利用结构变化的因果网络评价精神分裂症患者结构变化的因果关系。根据病程进行分级,并利用格兰杰因果关系分析T1加权图像。

结果为,随着病程的延长,丘脑灰质体积逐渐减小并累及到额叶,然后是颞叶、枕叶皮层及小脑(P < .00001)。结果显示丘脑是方位网络的中心并对额叶、颞叶、枕叶及小脑具有正性因果影响(P < .05)。额叶作为交接点,向枕叶、颞叶和小脑区域传递因果影响并接受丘脑产生的因果影响。

本研究表明,精神分裂症会出现进行性灰质异常,以丘脑为原发中心、额叶为节点。

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    2018-02-19 虈亣靌

    签到学习了--

    0

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    2018-02-18 Drhzm308

    谢谢.学习了

    0

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    2018-02-18 121832a9m88暂无昵称

    学习了

    0

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    2018-02-18 秀红

    学习了

    0

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