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Diabetes Care:含糖饮料的摄入变化与2型糖尿病风险

2019-10-04 xing.T MedSci原创

由此可见,含糖饮料或ASB的摄入量增加与2型糖尿病的发生风险有关,后者可能受到反向因果关系和监视偏倚的影响。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估含糖饮料(包括加糖饮料和100%的果汁)和人工甜味饮料(ASB)摄入的长期变化与随后2型糖尿病风险之间的相关性。

研究人员随访了护士健康研究(1986–2012)中76531名女性、护士健康研究II(1991–2013)中81597名女性和卫生专业人员后续研究(1986–2012)中34224名男性。根据每4年进行一次的食物频率问卷调查,计算出饮料消耗量的变化(以8盎司/天为单位)。研究人员使用多变量Cox比例回归模型来计算与饮料摄入量变化相关的糖尿病风险比,并使用反向方差加权固定效应荟萃分析汇总了这三个队列的结果。

在2783210人次每年的随访期间,研究人员记录了11906次2型糖尿病事件。在调整了BMI以及饮食和生活方式的初始变量和生活方式的协变量之后,在4年随访期间内,含糖饮料的总摄入量(包括含糖饮料和100%果汁)每天增加>0.50盎司与随后4年中糖尿病的风险增加16%(95%CI为1%-34%)相关。每天增加>0.50盎司/天的ASB摄入量会使糖尿病风险增加18%(2-36%)。每天用水、咖啡或茶,而非ASB代替含糖饮料,可使糖尿病风险降低2-10%。

由此可见,含糖饮料或ASB的摄入量增加与2型糖尿病的发生风险有关,后者可能受到反向因果关系和监视偏倚的影响。 

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