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Sci Rep：蛇床子素或是治疗牙周炎的一种有效药物

2017-07-19 MedSci MedSci原创

蛇床子素牙周炎
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炎性微环境可导致来源于牙周炎组织（P-PDLSCs）的牙周膜干细胞表观遗传修饰的变化，导致有缺陷的成骨细胞分化。现在亟需探讨可修复P-PDLSCs再生能力相关的表观遗传的治疗方法。Osthole，一种从中药中提取的小分子化合物，可促进健康的PDLSCs成骨细胞分化及细胞板的形成。然而，蛇床子素是否可同样影响P-PDLSCs，以及其促进作用的机制仍然是未知的。本研究旨在确定Osthole是否可以通过

炎性微环境可导致来源于牙周炎组织（P-PDLSCs）的牙周膜干细胞表观遗传修饰的变化，导致有缺陷的成骨细胞分化。现在亟需探讨可修复P-PDLSCs再生能力相关的表观遗传的治疗方法。

Osthole，一种从中药中提取的小分子化合物，可促进健康的PDLSCs成骨细胞分化及细胞板的形成。然而，蛇床子素是否可同样影响P-PDLSCs，以及其促进作用的机制仍然是未知的。

本研究旨在确定Osthole是否可以通过表观遗传修饰修复P-PDLSCs成骨细胞分化的缺陷。结果发现，10−7 mol/L蛇床子素是促进P-PDLSCs增殖和成骨分化的最佳浓度。理论上，此研究还发现，蛇床子素上调MOZ和MORF，以及组蛋白乙酰基转移酶，尤其是H3K9和H3K14，这些是P-PDLSCs成骨分化的关键调节因子。

此外，蛇床子素治疗可改善牙周炎动物模型中细胞板的形成和增强P-PDLSCs的骨形成。该研究表明，蛇床子素可通过调控表观遗传修饰用于治疗牙周炎。

原始出处：

Jin Sun, Zhiwei Dong, et al., Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering. Sci Rep. 2017; 7: 5254. Published online 2017 Jul 12. doi: 10.1038/s41598-017-05762-7.
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    2021-06-22 粹尘

    牙髓干细胞

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=975886, encodeId=d33a9e588680, content=牙髓干细胞, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=181a5531479, createdName=粹尘, createdTime=Tue Jun 22 18:54:45 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902630, encodeId=ee9e902630dc, content=<a href='/topic/show?id=59bd88606d2' target=_blank style='color:#2F92EE;'>#蛇床子素#</a>或是治疗<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>的一种有效药物 , beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88606, encryptionId=59bd88606d2, topicName=蛇床子素), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 26 22:24:15 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450568, encodeId=0c95145056805, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Jul 21 11:58:00 CST 2017, time=2017-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224022, encodeId=917c224022a7, content=好东西学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Jul 19 21:59:37 CST 2017, time=2017-07-19, status=1, ipAttribution=)]
    2020-11-26 lovetcm

    #蛇床子素#或是治疗#牙周炎#的一种有效药物

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=975886, encodeId=d33a9e588680, content=牙髓干细胞, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=181a5531479, createdName=粹尘, createdTime=Tue Jun 22 18:54:45 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902630, encodeId=ee9e902630dc, content=<a href='/topic/show?id=59bd88606d2' target=_blank style='color:#2F92EE;'>#蛇床子素#</a>或是治疗<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>的一种有效药物 , beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88606, encryptionId=59bd88606d2, topicName=蛇床子素), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 26 22:24:15 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450568, encodeId=0c95145056805, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Jul 21 11:58:00 CST 2017, time=2017-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224022, encodeId=917c224022a7, content=好东西学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Jul 19 21:59:37 CST 2017, time=2017-07-19, status=1, ipAttribution=)]
    2017-07-21 liuyong2982

    #牙周#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=975886, encodeId=d33a9e588680, content=牙髓干细胞, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=181a5531479, createdName=粹尘, createdTime=Tue Jun 22 18:54:45 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902630, encodeId=ee9e902630dc, content=<a href='/topic/show?id=59bd88606d2' target=_blank style='color:#2F92EE;'>#蛇床子素#</a>或是治疗<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>的一种有效药物 , beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88606, encryptionId=59bd88606d2, topicName=蛇床子素), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 26 22:24:15 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450568, encodeId=0c95145056805, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Jul 21 11:58:00 CST 2017, time=2017-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224022, encodeId=917c224022a7, content=好东西学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Jul 19 21:59:37 CST 2017, time=2017-07-19, status=1, ipAttribution=)]
    2017-07-19 thlabcde

    好东西学习了！

    0

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