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Neurology:中风后防痴呆?先从抑郁干预开始!

2021-04-15 MedSci原创 MedSci原创

脑卒中后整体及具体认知领域障碍都与卒中后抑郁高度相关,提前识别焦虑状态能为保护卒中后患者认知提供洞见。

卒中是最常见的脑血管意外,患者除偏瘫外,还可出现一系列情感行为的变化,其中抑郁和焦虑是脑卒中后常见的心理障碍。有研究表明只有39.5%的情感障碍和59.3%的焦虑障碍是以单独的形式出现的,而焦虑抑郁共病(CAD)则是最常见的共病模式。

其中,脑卒中后抑郁(PSD)是脑卒中后发生的抑郁症,属于继发性抑郁症的一种,是常见的脑血管病并发症之一。脑卒中发病率居高不下,PSD作为脑卒中的“副产品”,严重影响中风病患者的生活质量和功能康复,甚至危及生命。有关PSD发病率国内外文献报道均高达30%~40%。

而随着人口老龄化的加剧,卒中后认知障碍 (PSCI) 已经成为当今国际卒中研究和干预的热点。PSCI发病率日渐增高,给社会和家庭带来了沉重的经济负担。对于PSCI如何更好的诊治,是国内外医学界关注的重要问题。

不论是PSD、CAD还是PSCI,不仅影响患者的生存质量,也妨碍其神经功能的恢复,不仅给患者带来躯体上和精神上痛苦,而且增加了家庭和社会的负担。那么,卒中后6个月一般认知障碍和领域特异性认知障碍与抑郁和焦虑是否有关呢?

为此,来自英国牛津大学精神病学研究中心的专家发表在《神经病学》(Neurology)杂志上的研究给出了答案。研究人员招募了OCS-护理研究中确诊的437名急性脑卒中患者(平均年龄69.2岁),并在脑卒中后6个月的评估中进行随访。

抑郁和焦虑症状通过医院焦虑和抑郁子量表进行评估,分数大于7分表示可能存在情绪障碍。使用蒙特利尔认知评估(MoCA)评估随访时的整体认知障碍;使用牛津认知筛查(OCS)评估卒中特异性认知领域障碍。

结果显示,6个月随访时有115人(26%)诊断为抑郁症,133人(30%)诊断为焦虑症。总的来说,中风后6个月的抑郁状态与整体认知损伤(β = 0.96)和OCS评估的具体领域损伤均相关,后者主要包括空间注意力(β = 0.67)、执行功能(β = 1.37)、语言处理(β = 0.87)、记忆(β = 0.76)、数字处理(β = 1.13),和实践能力(β = 1.16)。

中风后焦虑则主要与整体认知损伤(β = 1.47)和空间注意(β = 1.25)障碍相关。但在控制共患中风后抑郁症后,上述焦虑与认知障碍之间的关联并不显著。

由此可见,脑卒中后整体及具体认知领域障碍都与卒中后抑郁高度相关,提前识别焦虑状态能为保护卒中后患者认知提供洞见。

 

参考文献:

Owen A. Williams, Nele Demeyere. Association of Depression and Anxiety With Cognitive Impairment 6 Months After Stroke. https://doi.org/10.1212/WNL.0000000000011748

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    2022-02-04 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2001303, encodeId=50b4200130398, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Feb 04 08:07:01 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963083, encodeId=b7649630836b, content=<a href='/topic/show?id=6b3a126981f' target=_blank style='color:#2F92EE;'>#Neurology#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12698, encryptionId=6b3a126981f, topicName=Neurology)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:45:46 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957536, encodeId=988695e536ee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/788a7f7e6afd44c2bbf80789f86648e5/d8e271f93c0842cca096818ad4390ccb.jpg, createdBy=69a95480157, createdName=妮妮阿, createdTime=Fri Apr 16 10:31:26 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046042, encodeId=0ab1104604297, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048762, encodeId=7f2d1048e6249, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957454, encodeId=e3de95e454ca, content=脑卒中是最常见的脑血管意外。, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Apr 15 23:26:08 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957451, encodeId=987295e45155, content=未病先防,将不可逆的病理改变扼杀在摇篮里, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210414/27b20c0636a6435c92d64d7350de689d/cda6f61951494ce8a28b23b5d2e73074.jpg, createdBy=4d9c5480623, createdName=沉下心, createdTime=Thu Apr 15 23:17:22 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-05-06 MedSciZeng

    #Neurology#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2001303, encodeId=50b4200130398, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Feb 04 08:07:01 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963083, encodeId=b7649630836b, content=<a href='/topic/show?id=6b3a126981f' target=_blank style='color:#2F92EE;'>#Neurology#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12698, encryptionId=6b3a126981f, topicName=Neurology)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:45:46 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957536, encodeId=988695e536ee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/788a7f7e6afd44c2bbf80789f86648e5/d8e271f93c0842cca096818ad4390ccb.jpg, createdBy=69a95480157, createdName=妮妮阿, createdTime=Fri Apr 16 10:31:26 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046042, encodeId=0ab1104604297, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048762, encodeId=7f2d1048e6249, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957454, encodeId=e3de95e454ca, content=脑卒中是最常见的脑血管意外。, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Apr 15 23:26:08 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957451, encodeId=987295e45155, content=未病先防,将不可逆的病理改变扼杀在摇篮里, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210414/27b20c0636a6435c92d64d7350de689d/cda6f61951494ce8a28b23b5d2e73074.jpg, createdBy=4d9c5480623, createdName=沉下心, createdTime=Thu Apr 15 23:17:22 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-16 妮妮阿

    学习

    0

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    2021-04-16 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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    2021-04-16 junJUN

    老年人痴呆何药可用??

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2001303, encodeId=50b4200130398, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Feb 04 08:07:01 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963083, encodeId=b7649630836b, content=<a href='/topic/show?id=6b3a126981f' target=_blank style='color:#2F92EE;'>#Neurology#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12698, encryptionId=6b3a126981f, topicName=Neurology)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:45:46 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957536, encodeId=988695e536ee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/788a7f7e6afd44c2bbf80789f86648e5/d8e271f93c0842cca096818ad4390ccb.jpg, createdBy=69a95480157, createdName=妮妮阿, createdTime=Fri Apr 16 10:31:26 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046042, encodeId=0ab1104604297, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048762, encodeId=7f2d1048e6249, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957454, encodeId=e3de95e454ca, content=脑卒中是最常见的脑血管意外。, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Apr 15 23:26:08 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957451, encodeId=987295e45155, content=未病先防,将不可逆的病理改变扼杀在摇篮里, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210414/27b20c0636a6435c92d64d7350de689d/cda6f61951494ce8a28b23b5d2e73074.jpg, createdBy=4d9c5480623, createdName=沉下心, createdTime=Thu Apr 15 23:17:22 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 言西早

    脑卒中是最常见的脑血管意外。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2001303, encodeId=50b4200130398, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Feb 04 08:07:01 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=963083, encodeId=b7649630836b, content=<a href='/topic/show?id=6b3a126981f' target=_blank style='color:#2F92EE;'>#Neurology#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12698, encryptionId=6b3a126981f, topicName=Neurology)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:45:46 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957536, encodeId=988695e536ee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/788a7f7e6afd44c2bbf80789f86648e5/d8e271f93c0842cca096818ad4390ccb.jpg, createdBy=69a95480157, createdName=妮妮阿, createdTime=Fri Apr 16 10:31:26 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046042, encodeId=0ab1104604297, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048762, encodeId=7f2d1048e6249, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Apr 16 01:07:01 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957454, encodeId=e3de95e454ca, content=脑卒中是最常见的脑血管意外。, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Apr 15 23:26:08 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957451, encodeId=987295e45155, content=未病先防,将不可逆的病理改变扼杀在摇篮里, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210414/27b20c0636a6435c92d64d7350de689d/cda6f61951494ce8a28b23b5d2e73074.jpg, createdBy=4d9c5480623, createdName=沉下心, createdTime=Thu Apr 15 23:17:22 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 沉下心

    未病先防,将不可逆的病理改变扼杀在摇篮里

    0

拓展阅读

ISC 2024:中风后痴呆的发生风险和时间进程——2002-2022 年全人群队列研究

与匹配的对照组相比,卒中患者患痴呆的风险高出 80%。这种风险在中风后早期最高,但在 20 年后仍然很高

neurology:这些因素与脑卒中后认知功能的短期轨迹——STROKOG合作研究

卒中后3.6个月以上的基线认知功能是长期认知结果的良好预测因素。年龄较大、教育程度较低、糖尿病、大动脉卒中和卒中严重程度较高是第一年认知能力下降的危险因素。

Neurology:年轻卒中幸存者的卒中后癫痫发作和痴呆风险

年轻卒中幸存者新发作的癫痫对随后发展为痴呆症的影响尚不清楚。近日,一项以人群为基础的卒中患者研究发现,年轻卒中幸存者的癫痫发作与发展为痴呆症的风险增加2.53倍相关。

Stroke:卒中复发及卒中后痴呆与卒中前血管危险因素相关

背景:改善脑卒中后短期生存有必要量化长期后遗症(即复发性中风和痴呆)的风险及危险因素。这种风险可能会受卒中前心血管疾病的危险因素的影响。在鹿特丹以人口为基础的研究中,研究者确定复发性卒中和痴呆长期风险,并探讨了卒中前心血管危险因素影响复发性卒中和卒中后痴呆症的比例。(即人群归因危险度)。方法:研究者随访了1237例首发的脑卒中患者和,按照年龄,性别,检查周期及卒中日期(指数日期)相匹配的4928无

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