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Onco Targets Ther:研究发现lncRNA LEF1-AS1或是治疗胶质母细胞瘤的关键

2017-09-24 MedSci MedSci原创

研究已经证实胶质母细胞瘤(GBM)组织中长链非编码RNA(lncRNA)是不同细胞过程的关键调节剂。然而,lncRNA的表达模式和生物学功能在很大程度上是未知的。在这里,研究人员首次探究了lncRNA淋巴增强子结合因子1反义RNA 1(LEF1-AS1)在体外和体内对GBM进展的影响。研究人员通过生物信息学分析研究了GBM标本中LEF1-AS1的表达谱。使用定量聚合酶链反应检测GBM组织中的LEF

研究已经证实胶质母细胞瘤(GBM)组织中长链非编码RNA(lncRNA)是不同细胞过程的关键调节剂。然而,lncRNA的表达模式和生物学功能在很大程度上是未知的。在这里,研究人员首次探究了lncRNA淋巴增强子结合因子1反义RNA 1(LEF1-AS1)在体外和体内对GBM进展的影响。

研究人员通过生物信息学分析研究了GBM标本中LEF1-AS1的表达谱。使用定量聚合酶链反应检测GBM组织中的LEF1-AS1表达。通过转染LEF1-AS1特异性小干扰RNA(siRNA)抑制LEF1-AS1的表达,并通过转染si-LEF1-AS1病毒抑制稳定细胞系。使用细胞计数试剂盒-8,乙炔基脱氧尿苷和集落形成法检测细胞的增殖功能。流式细胞术用于检测细胞周期变化和细胞凋亡。通过Transwell测定法检测细胞的迁移效应。使用肿瘤异种移植物和免疫组织化学以评价体内肿瘤的生长。

结果显示,与正常组织相比,GBM样本中LEF1-AS1的表达显著上调。来自LEF1-AS1高表达的癌症基因组图谱的GBM患者的5年总体生存率低于低表达者。GBF组织中LEF1-AS1的表达高于正常组织。敲除LEF1-AS1可显著抑制GBM细胞的恶性表现,包括细胞的增殖和侵袭,并可促进细胞凋亡。Western blot分析结果表明,敲除GBM细胞中LEF1-AS1介导的肿瘤抑制或是通过降低ERK和Akt / mTOR信号传导活性的而实现。最后,体内实验也证明,敲除LEF1-AS1可抑制U87细胞LEF1-AS1的生长促进作用。

总之,该结果表明,lncRNA LEF1-AS1作为GBM的一种癌基因,或是治疗这种疾病的关键点。

原始出处:


Jin Wang, Xiaoyang Liu, et al., LEF1-AS1, a long-noncoding RNA, promotes malignancy in glioblastoma. Onco Targets Ther. 2017; 10: 4251–4260. Published online 2017 Aug 28. doi: 10.2147/OTT.S130365

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    2017-12-29 仁医06
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    2017-09-26 luominglian113

    学习了.谢谢分享

    0

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    2017-09-26 xzw113
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终于,在克利夫兰诊所Jeremy Rich教授团队的不懈努力下,一种体内筛选抗肿瘤药物靶点的新方法诞生了! Rich教授是胶质母细胞瘤领域的专家,可是对于这种侵袭性极强,中位生存期只有15个月,5年生存率在6%左右,被称为「癌症之王」的癌症,他也束手无策。 在Rich教授看来,这可能是研究的方法出了问题。 「传统药物研发是从体外培养癌细胞开始的,然后做高通量筛选。」Rich教授在论文中表

Neuroradiology:RANO标准、对比增强和灌注MRI在评估胶质母细胞瘤进展的价值。

多形性胶质母细胞瘤简称为胶母细胞瘤,按Kernohan分类属星形细胞瘤3~4级。胶质母细胞瘤是最常见的脑胶质瘤之一,占胶质瘤的25%以上,也是最恶性的一种。男性多于女性,男女之比约为3:1。大多发生于成人,特别是30~50岁间。胶质母细胞瘤呈浸润性生长,病程迅速进展,手术切除后常很快复发。本研究旨在评价多形性胶质母细胞瘤(GBM)神经肿瘤反应评价标准关于Macdonald标准和对比增强(CE)体积

Redox Biol:恢复胶质母细胞瘤治疗敏感性的潜在治疗靶点

胶质母细胞瘤是星形细胞肿瘤中恶性程度最高的胶质瘤。肿瘤位于皮质下,多数生长于幕上大脑半球各处。呈浸润性生长,常侵犯几个脑叶,并侵犯深部结构,还可经胼胝体波及对侧大脑半球。

Oncotarget:PARP1表达和TP53状态是区分胶质母细胞瘤亚型可靠标记物

胶质母细胞瘤(GBM)是星形细胞肿瘤中恶性程度最高的胶质瘤。肿瘤位于皮质下,多数生长于幕上大脑半球各处。

Nat Neurosci:华人学者千里挑一,找到脑瘤致命基因突变

来自耶鲁大学(Yale University)系统生物学研究所的Sidi Chen教授团队与瑞士的Randall Platt教授课题组合作,用CRISPR技术,成功找到了导致胶质母细胞瘤的关键基因突变。这项研究发表在了《自然》子刊《Nature Neuroscience》上

Sci Transl Med:重磅疗法治疗脑瘤,研究展现曙光

在一项临床试验中,研究人员们招募了一批表达EGFRvIII,且病情出现复发的胶质母细胞瘤患者。利用这些患者体内的T细胞,研究人员开发出了CAR-T-EGFRvIII疗法,特异性地针对患者的癌细胞。

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