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Am J Gastroenterol:嗜酸性粒细胞性食管炎疾病活动指数评估方法

2017-10-18 zhangfan MedSci原创

研究从组织学、内镜检测、疾病症状等方面建立了嗜酸性粒细胞性食管炎疾病活动指数的评估手段,该研究将为疾病的诊断和治疗提供新的依据

目前关于嗜酸性粒细胞性食管炎(EOE)疾病活动指数的评估尚无统一共识,近日研究人员针对EoE疾病活动指数的评价方法进行了相关研究。

研究人员对截止2016年5月的相关研究进行收集,关于EOE疾病活动或治疗响应的随机对照,队列,案例控制和横断面研究均纳入本次荟萃分析,根据FDA指南,严格评价了疾病的组织学、内镜、病人报告症状以及健康相关生活质量的影响。

总计4373项指标,130个研究纳入本次荟萃分析。尽管无指标符合所有的评价标准,研究人员认为:(1) EOE组织学评分系统(EOEHSS)是最有效的组织学评估手段;(2)内窥镜参考评分(EREFS)是最可靠和快速的内窥镜评估手段;(3) 嗜酸性食管炎活性指数(EESAI)或吞咽困难症状问卷(DSQ)是成年患者症状严重程度的有效评估方法, EoE儿童生活质量问卷是评估儿童疾病症状的有效方法。

研究从组织学、内镜检测、疾病症状等方面建立了嗜酸性粒细胞性食管炎疾病活动指数的评估手段,该研究将为疾病的诊断和治疗提供新的依据。

原始出处:

Marijn J Warners et al. Systematic Review: Disease Activity Indices in Eosinophilic Esophagitis.Am J Gastroenterol. 17 October 2017.

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    2018-06-14 许安
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  8. 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    2017-10-20 zhouqu_8
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