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孕期生殖器疱疹可能会增加后代患自闭症的风险

2017-02-23 tulip1999 来宝网

一项最新研究表明,怀孕期间患活跃性生殖器疱疹的母亲其所生的孩子患自闭症谱系障碍的几率翻倍。

一项最新研究表明,怀孕期间患活跃性生殖器疱疹的母亲其所生的孩子患自闭症谱系障碍的几率翻倍。

该研究的责任作者,挪威公共卫生研究所及感染与免疫中心的 Milada Mahic 及其同事在 mSphere 杂志上发表了他们的研究结果。 生殖器疱疹是一种常见的性传播感染,主要是由单纯疱疹病毒 2 型(HSV-2)引起的。

全世界约有 4 亿 1 千 700 万人患有由单纯疱疹病毒 2 型所致的生殖器疱疹,在所有患病人群中只有 10-20% 能够得到早起诊断。

女性受单纯疱疹病毒 2 型感染比男性更为常见;在美国 14-49 岁之间的女性当中大约有 20.3% 发生 HSV-2 感染,相比之下,只有 10.6% 的男性发生 HSV-2 感染。 最新研究表明,怀孕期间对感染的免疫反应与后代自闭症谱系障碍(ASD)风险增加之间存在关联。

研究人员指出,怀孕 18 周是胎儿神经系统快速生长发育的时期。因此,他们推测,母体发生的针对 HSV-2 的免疫反应可能会影响胎儿神经系统的发育,这就可能会增加患自闭症的风险。 然而,他们指出,该项研究只包括一小部分的 ASD 女性,所以他们无法判断他们的结果是否表现为性别特异性。不过,他们指出,男孩比女孩更常发生 ASD。

虽然还需要进一步的研究来更好地了解在怀孕期间 HSV-2 感染与后代 ASD 风险之间存在的关联,但研究人员相信,他们的发现揭示了 ASD 的潜在原因。“大多数自闭症病例的病因是未知的。但有证据表明是遗传和环境因素共同作用的结果。

我们的研究结果表明,炎症反应和免疫激活可能会促进后代 ASD 风险增加。单纯疱疹病毒 - 2 可以是任何相关的传染性病原体之一。” 感染与免疫中心的资深作者 W. Ian Lipkin 如是说。

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    2017-02-25 xiongke014
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