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Dig Liver Dis: 自身免疫性肝炎患者血清免疫球蛋白G水平正常化与无移植生存期改善有关

2020-08-13 MedSci原创 MedSci原创

自身免疫性肝病(AIH)是一种特殊类型的慢性肝病,被称为“自身免疫性肝病”、“自身免疫活动性慢性肝炎”。其性别、年龄分布与红斑狼疮相似,且常伴有肝外症状,甚至可见“狼疮”现象。

        自身免疫性肝病(AIH)是一种特殊类型的慢性肝病,被称为“自身免疫性肝病”、“自身免疫活动性慢性肝炎”。其性别、年龄分布与红斑狼疮相似,且常伴有肝外症状,甚至可见“狼疮”现象,因而推测其发病与自身免疫有关。

        而目前尚没有很好地生物学指标来判断AIH的预后,血清免疫球蛋白G(IgG)水平的正常化开始获得越来越多的关注,本项研究旨在调查与AIH影响的患者死亡或肝移植相关的因素。

https://doi.org/10.1016/j.dld.2020.04.012

        研究人员将符合纳入标准的107名患者纳入研究。诊断时的平均年龄为44岁,基线时有肝硬化的患者29例(占27.1%)。中位随访时间为79个月,有70例患者(79.5%)达到了生化反应。生化反应与减少肝移植或死亡的危险有关(HR 0.07,95%CI 0.01-0.46),而诊断时的肝硬化是肝移植或死亡的独立预测因子(危险比(HR)11.8,95%CI置信区间1.18–117.4)。血清IgG水平缺乏正常化与5年无移植生存期降低相关。

        因此,本项研究通过人体试验证实单独的血清IgG水平正常化可改善AIH患者的无移植生存期,应与转氨酶一起作为治疗目标。

 

原始出处:

Alessio Gerussi. Et al. Normalization of serum immunoglobulin G levels is associated with improved transplant-free survival in patients with autoimmune hepatitis.  Dig Liver Dis.2020.

 

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    2020-09-26 xzw113
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