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硫胺素长期肠外给药可作为韦尼克—科尔萨科夫综合征美金刚疗法辅助手段

2013-07-30 wangrui cmt

韦尼克脑病及科尔萨科夫氏精神病是愈后不良的酒精性脑病的严重的不利形式。硫胺素缺乏为两种疾病的常见病因。在许多病例中,伴随着一般病因,科尔萨科夫氏精神病出现在韦尼克脑病的转归中。就单一疾病韦尼克—科尔萨科夫综合征而言,其急性期(通常是可逆的)表现为韦尼克脑病,慢性期(通常是不可逆的)为科尔萨科夫氏精神病。 俄罗斯研究人员发现在韦尼克脑病的治疗中存在一种戏剧性的矛盾,即在大多数病例中,韦尼克脑病都较

韦尼克脑病及科尔萨科夫氏精神病是愈后不良的酒精性脑病的严重的不利形式。硫胺素缺乏为两种疾病的常见病因。在许多病例中,伴随着一般病因,科尔萨科夫氏精神病出现在韦尼克脑病的转归中。就单一疾病韦尼克—科尔萨科夫综合征而言,其急性期(通常是可逆的)表现为韦尼克脑病,慢性期(通常是不可逆的)为科尔萨科夫氏精神病。

俄罗斯研究人员发现在韦尼克脑病的治疗中存在一种戏剧性的矛盾,即在大多数病例中,韦尼克脑病都较难被察觉,但早期诊断病例却非常容易治愈。未辨识的及因此而未得到治疗的韦尼克脑病对患者的健康和生命是一种严重的威胁,其可加速大脑衰老并增加晚年阿尔兹海默氏病患病风险。长期高剂量硫胺素肠外给药是韦尼克—科尔萨科夫综合征的基本治疗方法,将其作为美金刚疗法的辅助疗法是值得考虑的。

原始出处:

Sivolap IP, Damulin IV.[Wernicke encephalopathy and Korsakoff's psychosis: clinical-pathophysiological correlation, diagnostics and treatment.]Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(6 Vypusk 2 Alkogolizm):20-26. Russian.

PMID:
23887463

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    2013-08-01 sjq030
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