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J Gastroenterol Hepatol：胆结石患者小肠细菌过度生长的特点

2018-08-27 MedSci MedSci原创

细菌过度生长胆结石胆囊切除
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小肠细菌过度生长在胆结石患者中很常见。特别是CH4或混合型，SIBO似乎普遍存在，使肠道症状加重。

研究背景和目的：小肠细菌过度生长(SIBO)可能在胆结石疾病中很常见，包括胆囊切除术和胆结石。本研究旨在探讨胆结石患者SIBO的患病率及特点。

研究方法：该项前瞻性研究评估了265例胆结石（200例胆结石和65例胆囊切除）和39例健康对照者的数据。分析实验室数据、腹部超声及葡萄糖呼吸试验(GBT)以及进行肠道症状问卷。

研究结果：胆结石患者葡萄糖呼吸试验阳性率(+)(36.6%)明显高于对照组(20.5%)患者。胆结石组GBT+(40.5%)明显高于对照组或胆囊切除术组(24.6%)。胆结石患者中，GBT (H2)+、(CH4)+、(混合)+组(56例[28.0%]、11例[5.5%]、14例[7.00%])的发生率较高。胆囊疾病与脂肪肝、代谢综合征和SIBO等独立相关。在97例GBT+患者中，分别有70例(72.1%)、12例(12.4%)和15例(15.5%)属于GBT (H2)+、(CH4)+和(混合)+组。与胆囊切除术组相比，胆结石组与GBT (CH4)+或GBT(混合)+显著相关。GBT(混合)+组在硬卧和急症倾向方面的症状得分高于GBT-组或GBT (H2)+组相比GBT-组，有硬卧和疏松倾向方面的趋势。胆结石是胆结石疾病患者SIBO的唯一独立因素。

研究结论：小肠细菌过度生长在胆结石患者中很常见。特别是CH4或混合型，SIBO似乎普遍存在，使肠道症状加重。

原始出处

Kim DB， Paik CN， Song DS， et al. The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases. J Gastroenterol Hepatol， 2018， 33(8)， 1477-1484.

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    2018-11-19 jktdtl

    #Gastroenterol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2064458, encodeId=71902064458ac, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Nov 19 18:22:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711604, encodeId=f9ed1e1160413, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Mar 10 18:22:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072256, encodeId=94bf20e2256cf, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Dec 15 21:22:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427204, encodeId=0824142e20460, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Aug 29 09:22:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341493, encodeId=dd13341493c9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Aug 28 18:47:10 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2019-03-10 ms24272190615788285182

    #AST#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2064458, encodeId=71902064458ac, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Nov 19 18:22:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711604, encodeId=f9ed1e1160413, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Mar 10 18:22:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072256, encodeId=94bf20e2256cf, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Dec 15 21:22:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427204, encodeId=0824142e20460, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Aug 29 09:22:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341493, encodeId=dd13341493c9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Aug 28 18:47:10 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-12-15 许安

    #GAS#

    0

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    2018-08-29 gwc384

    #EPA#

    0

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    2018-08-28 131****1460

    学习了受益匪浅

    0

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